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GPCR

NameG-protein coupled receptor 84
SpeciesHomo sapiens (Human)
GeneGPR84
SynonymGPCR4
GPR84
Inflammation-related G-protein coupled receptor EX33
DiseaseN/A
Length396
Amino acid sequenceMWNSSDANFSCYHESVLGYRYVAVSWGVVVAVTGTVGNVLTLLALAIQPKLRTRFNLLIANLTLADLLYCTLLQPFSVDTYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALGRYLLIAHPKLFPQVFSAKGIVLALVSTWVVGVASFAPLWPIYILVPVVCTCSFDRIRGRPYTTILMGIYFVLGLSSVGIFYCLIHRQVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQELDSRLASGGPSEGISSEPVSAATTQTLEGDSSEVGDQINSKRAKQMAEKSPPEASAKAQPIKGARRAPDSSSEFGKVTRMCFAVFLCFALSYIPFLLLNILDARVQAPRVVHMLAANLTWLNGCINPVLYAAMNRQFRQAYGSILKRGPRSFHRLH
UniProtQ9NQS5
Protein Data BankN/A
GPCR-HGmod modelQ9NQS5
3D structure modelThis predicted structure model is from GPCR-EXP Q9NQS5.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3714079
IUPHAR120
DrugBankN/A

Ligand

NameCHEMBL3715772
Molecular formulaC25H26N2O4
IUPAC name2-(oxolan-2-ylmethoxy)-9-(2-phenylethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one
Molecular weight418.493
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP3.9
SynonymsSCHEMBL15825229
Inchi KeyHNKQMNAXSPPXFC-UHFFFAOYSA-N
Inchi IDInChI=1S/C25H26N2O4/c28-25-26-24(31-17-21-7-4-13-29-21)16-23-22-9-8-20(15-19(22)10-12-27(23)25)30-14-11-18-5-2-1-3-6-18/h1-3,5-6,8-9,15-16,21H,4,7,10-14,17H2
PubChem CID76684660
ChEMBLCHEMBL3715772
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50100.0 nMNoneChEMBL

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