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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Rattus norvegicus (Rat)
Gene	Mchr1
Synonym	SLC-1 MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 somatostatin receptor-like protein [ Show all ]
Disease	N/A for non-human GPCRs
Length	353
Amino acid sequence	MDLQTSLLSTGPNASNISDGQDNLTLPGSPPRTGSVSYINIIMPSVFGTICLLGIVGNSTVIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMTIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
UniProt	P97639
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1075228
IUPHAR	280
DrugBank	N/A

Ligand

Name	CHEMBL3793625
Molecular formula	C24H22ClN3O2
IUPAC name	4-[(4-chlorophenyl)methoxy]-1-(2-cyclopropyl-3-ethylbenzimidazol-5-yl)pyridin-2-one
Molecular weight	419.909
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	4.2
Synonyms	BDBM50161850 HGMHZLGJIPRCMS-UHFFFAOYSA-N 4-((4-Chlorobenzyl)oxy)-1-(2-cyclopropyl-1-ethyl-1H-benzimidazol-6-yl)pyridin-2(1H)-one SCHEMBL15112265
Inchi Key	HGMHZLGJIPRCMS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H22ClN3O2/c1-2-27-22-13-19(9-10-21(22)26-24(27)17-5-6-17)28-12-11-20(14-23(28)29)30-15-16-3-7-18(25)8-4-16/h3-4,7-14,17H,2,5-6,15H2,1H3
PubChem CID	89691247
ChEMBL	CHEMBL3793625
IUPHAR	N/A
BindingDB	50161850
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	34.0 nM	PMID27112449	ChEMBL

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