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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	G-protein coupled receptor 84
Species	Homo sapiens (Human)
Gene	GPR84
Synonym	GPCR4 GPR84 Inflammation-related G-protein coupled receptor EX33
Disease	N/A
Length	396
Amino acid sequence	MWNSSDANFSCYHESVLGYRYVAVSWGVVVAVTGTVGNVLTLLALAIQPKLRTRFNLLIANLTLADLLYCTLLQPFSVDTYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALGRYLLIAHPKLFPQVFSAKGIVLALVSTWVVGVASFAPLWPIYILVPVVCTCSFDRIRGRPYTTILMGIYFVLGLSSVGIFYCLIHRQVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQELDSRLASGGPSEGISSEPVSAATTQTLEGDSSEVGDQINSKRAKQMAEKSPPEASAKAQPIKGARRAPDSSSEFGKVTRMCFAVFLCFALSYIPFLLLNILDARVQAPRVVHMLAANLTWLNGCINPVLYAAMNRQFRQAYGSILKRGPRSFHRLH
UniProt	Q9NQS5
Protein Data Bank	N/A
GPCR-HGmod model	Q9NQS5
3D structure model	This predicted structure model is from GPCR-EXP Q9NQS5.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3714079
IUPHAR	120
DrugBank	N/A

Ligand

Name	CHEMBL3719125
Molecular formula	C19H21FN2O5
IUPAC name	2-[[(2S)-1,4-dioxan-2-yl]methoxy]-9-(2-fluoroethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one
Molecular weight	376.384
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	1.4
Synonyms	SCHEMBL15051024
Inchi Key	HDGSQKHLTYKQFN-HNNXBMFYSA-N
Inchi ID	InChI=1S/C19H21FN2O5/c20-4-6-25-14-1-2-16-13(9-14)3-5-22-17(16)10-18(21-19(22)23)27-12-15-11-24-7-8-26-15/h1-2,9-10,15H,3-8,11-12H2/t15-/m0/s1
PubChem CID	89645424
ChEMBL	CHEMBL3719125
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	501.0 nM	None	ChEMBL

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