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GPCR

NameG-protein coupled receptor 6
SpeciesHomo sapiens (Human)
GeneGPR6
SynonymGPR6
Sphingosine 1-phosphate receptor GPR6
DiseaseN/A
Length362
Amino acid sequenceMNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV
UniProtP46095
Protein Data BankN/A
GPCR-HGmod modelP46095
3D structure modelThis predicted structure model is from GPCR-EXP P46095.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3714130
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3715860
Molecular formulaC22H25ClN6O
IUPAC name5-chloro-1-[[1-[2-(cyclopropylamino)-7-methylpyrido[3,4-b]pyrazin-3-yl]piperidin-4-yl]methyl]pyridin-2-one
Molecular weight424.933
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP3.1
SynonymsSCHEMBL15566172
Inchi KeyHCKHIDZTZVVYHI-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H25ClN6O/c1-14-10-18-19(11-24-14)27-22(21(26-18)25-17-3-4-17)28-8-6-15(7-9-28)12-29-13-16(23)2-5-20(29)30/h2,5,10-11,13,15,17H,3-4,6-9,12H2,1H3,(H,25,26)
PubChem CID90038198
ChEMBLCHEMBL3715860
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50770.0 nMNoneChEMBL

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