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Name | 5-hydroxytryptamine receptor 7 |
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Species | Homo sapiens (Human) |
Gene | HTR7 |
Synonym | 5-HT-7 Serotonin receptor 7 5-HT-X 5-HT1Y 5-HT7 [ Show all ] |
Disease | Sleep disorders Schizophrenia Major depressive disorder |
Length | 479 |
Amino acid sequence | MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD |
UniProt | P34969 |
Protein Data Bank | N/A |
GPCR-HGmod model | P34969 |
3D structure model | This predicted structure model is from GPCR-EXP P34969. |
BioLiP | N/A |
Therapeutic Target Database | T79062 |
ChEMBL | CHEMBL3155 |
IUPHAR | 12 |
DrugBank | BE0000650, BE0004862 |
Name | CHEMBL258075 |
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Molecular formula | C12H17N3O |
IUPAC name | 4-methyl-8-propan-2-yloxy-1,4-dihydroquinazolin-2-amine |
Molecular weight | 219.288 |
Hydrogen bond acceptor | 2 |
Hydrogen bond donor | 2 |
XlogP | 1.3 |
Synonyms | 2-Quinazolinamine, 1,4-dihydro-4-methyl-8-(1-methylethoxy)- DTXSID10581057 918136-35-3 4-Methyl-8-[(propan-2-yl)oxy]-1,4-dihydroquinazolin-2-amine SCHEMBL1379218 [ Show all ] |
Inchi Key | CWVMKYZWIKCBIY-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C12H17N3O/c1-7(2)16-10-6-4-5-9-8(3)14-12(13)15-11(9)10/h4-8H,1-3H3,(H3,13,14,15) |
PubChem CID | 16006607 |
ChEMBL | CHEMBL258075 |
IUPHAR | N/A |
BindingDB | 50371462 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 1.0 nM | PMID17998160 | BindingDB,ChEMBL |
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