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GPCR

NameG-protein coupled receptor 6
SpeciesHomo sapiens (Human)
GeneGPR6
SynonymGPR6
Sphingosine 1-phosphate receptor GPR6
DiseaseN/A
Length362
Amino acid sequenceMNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV
UniProtP46095
Protein Data BankN/A
GPCR-HGmod modelP46095
3D structure modelThis predicted structure model is from GPCR-EXP P46095.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3714130
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3718003
Molecular formulaC22H25F3N6O3
IUPAC nameN-cyclopropyl-3-[4-[(5-methyl-1,2-oxazol-3-yl)methyl]piperazin-1-yl]quinoxalin-2-amine;2,2,2-trifluoroacetic acid
Molecular weight478.476
Hydrogen bond acceptor12
Hydrogen bond donor2
XlogPNone
SynonymsN/A
Inchi KeyGSEBIDRFAWJZMG-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H24N6O.C2HF3O2/c1-14-12-16(24-27-14)13-25-8-10-26(11-9-25)20-19(21-15-6-7-15)22-17-4-2-3-5-18(17)23-20;3-2(4,5)1(6)7/h2-5,12,15H,6-11,13H2,1H3,(H,21,22);(H,6,7)
PubChem CID127024195
ChEMBLCHEMBL3718003
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
IC50105440.0 nMNoneChEMBL

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