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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Rattus norvegicus (Rat)
Gene	Mchr1
Synonym	SLC-1 MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 somatostatin receptor-like protein [ Show all ]
Disease	N/A for non-human GPCRs
Length	353
Amino acid sequence	MDLQTSLLSTGPNASNISDGQDNLTLPGSPPRTGSVSYINIIMPSVFGTICLLGIVGNSTVIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMTIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
UniProt	P97639
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1075228
IUPHAR	280
DrugBank	N/A

Ligand

Name	CHEMBL3793953
Molecular formula	C23H21N3O2
IUPAC name	1-(2-cyclopropyl-3-methylbenzimidazol-5-yl)-4-phenylmethoxypyridin-2-one
Molecular weight	371.44
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	3.2
Synonyms	BDBM50163437 GMKUXLCFJXBODY-UHFFFAOYSA-N 4-(Benzyloxy)-1-(2-cyclopropyl-1-methyl-1H-benzimidazol-6-yl)pyridin-2(1H)-one SCHEMBL15111971
Inchi Key	GMKUXLCFJXBODY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H21N3O2/c1-25-21-13-18(9-10-20(21)24-23(25)17-7-8-17)26-12-11-19(14-22(26)27)28-15-16-5-3-2-4-6-16/h2-6,9-14,17H,7-8,15H2,1H3
PubChem CID	89691032
ChEMBL	CHEMBL3793953
IUPHAR	N/A
BindingDB	50163437
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	43.0 nM	PMID27112449	ChEMBL

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