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GPCR

NameG-protein coupled receptor 6
SpeciesHomo sapiens (Human)
GeneGPR6
SynonymGPR6
Sphingosine 1-phosphate receptor GPR6
DiseaseN/A
Length362
Amino acid sequenceMNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV
UniProtP46095
Protein Data BankN/A
GPCR-HGmod modelP46095
3D structure modelThis predicted structure model is from GPCR-EXP P46095.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3714130
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3717381
Molecular formulaC23H24F4N6O4
IUPAC nameN-cyclopropyl-3-[4-(2-fluoro-4-methoxyphenoxy)piperidin-1-yl]pyrazino[2,3-d]pyridazin-2-amine;2,2,2-trifluoroacetic acid
Molecular weight524.477
Hydrogen bond acceptor14
Hydrogen bond donor2
XlogPNone
SynonymsN/A
Inchi KeyFUBLJJZAFRFLQH-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H23FN6O2.C2HF3O2/c1-29-15-4-5-19(16(22)10-15)30-14-6-8-28(9-7-14)21-20(25-13-2-3-13)26-17-11-23-24-12-18(17)27-21;3-2(4,5)1(6)7/h4-5,10-14H,2-3,6-9H2,1H3,(H,25,26);(H,6,7)
PubChem CID127024291
ChEMBLCHEMBL3717381
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
IC5020.0 nMNoneChEMBL

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