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GPCR

NameG-protein coupled receptor 84
SpeciesHomo sapiens (Human)
GeneGPR84
SynonymGPCR4
GPR84
Inflammation-related G-protein coupled receptor EX33
DiseaseN/A
Length396
Amino acid sequenceMWNSSDANFSCYHESVLGYRYVAVSWGVVVAVTGTVGNVLTLLALAIQPKLRTRFNLLIANLTLADLLYCTLLQPFSVDTYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALGRYLLIAHPKLFPQVFSAKGIVLALVSTWVVGVASFAPLWPIYILVPVVCTCSFDRIRGRPYTTILMGIYFVLGLSSVGIFYCLIHRQVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQELDSRLASGGPSEGISSEPVSAATTQTLEGDSSEVGDQINSKRAKQMAEKSPPEASAKAQPIKGARRAPDSSSEFGKVTRMCFAVFLCFALSYIPFLLLNILDARVQAPRVVHMLAANLTWLNGCINPVLYAAMNRQFRQAYGSILKRGPRSFHRLH
UniProtQ9NQS5
Protein Data BankN/A
GPCR-HGmod modelQ9NQS5
3D structure modelThis predicted structure model is from GPCR-EXP Q9NQS5.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3714079
IUPHAR120
DrugBankN/A

Ligand

NameCHEMBL3716334
Molecular formulaC27H29N3O5
IUPAC name2-(2,3-dihydro-1,4-benzodioxin-3-ylmethoxy)-9-(2-pyrrolidin-1-ylethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one
Molecular weight475.545
Hydrogen bond acceptor6
Hydrogen bond donor0
XlogP3.5
SynonymsSCHEMBL15825825
Inchi KeyFLTYZNHFYKQPKJ-UHFFFAOYSA-N
Inchi IDInChI=1S/C27H29N3O5/c31-27-28-26(34-18-21-17-33-24-5-1-2-6-25(24)35-21)16-23-22-8-7-20(15-19(22)9-12-30(23)27)32-14-13-29-10-3-4-11-29/h1-2,5-8,15-16,21H,3-4,9-14,17-18H2
PubChem CID76684895
ChEMBLCHEMBL3716334
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50100.0 nMNoneChEMBL

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