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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Rattus norvegicus (Rat)
Gene	Mchr1
Synonym	SLC-1 MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 somatostatin receptor-like protein [ Show all ]
Disease	N/A for non-human GPCRs
Length	353
Amino acid sequence	MDLQTSLLSTGPNASNISDGQDNLTLPGSPPRTGSVSYINIIMPSVFGTICLLGIVGNSTVIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMTIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
UniProt	P97639
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1075228
IUPHAR	280
DrugBank	N/A

Ligand

Name	CHEMBL3793182
Molecular formula	C23H22FN3O2
IUPAC name	4-[(4-fluorophenyl)methoxy]-1-(3-methyl-2-propylbenzimidazol-5-yl)pyridin-2-one
Molecular weight	391.446
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	3.9
Synonyms	BDBM50163465 FJNVAWAOWNBJEP-UHFFFAOYSA-N 4-((4-Fluorobenzyl)oxy)-1-(1-methyl-2-propyl-1H-benzimidazol-6-yl)pyridin-2(1H)-one SCHEMBL15112688
Inchi Key	FJNVAWAOWNBJEP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H22FN3O2/c1-3-4-22-25-20-10-9-18(13-21(20)26(22)2)27-12-11-19(14-23(27)28)29-15-16-5-7-17(24)8-6-16/h5-14H,3-4,15H2,1-2H3
PubChem CID	89691535
ChEMBL	CHEMBL3793182
IUPHAR	N/A
BindingDB	50163465
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	39.0 nM	PMID27112449	ChEMBL

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