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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 4
Species	Rattus norvegicus (Rat)
Gene	Htr4
Synonym	5-HT-4 5-HT4 5-HT4 receptor 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled serotonin receptor 4
Disease	N/A for non-human GPCRs
Length	406
Amino acid sequence	MDRLDANVSSNEGFGSVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVNAFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRDTVECGGQWESRCHLTATSPLVAAQPVIRRPQDNDLEDSCSLKRSQS
UniProt	Q62758
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4317
IUPHAR	9
DrugBank	N/A

Ligand

Name	CHEMBL3758945
Molecular formula	C22H33ClN4O4
IUPAC name	4-amino-5-chloro-2-methoxy-N-[(3R,4S)-3-methoxy-1-(3-oxo-3-piperidin-1-ylpropyl)piperidin-4-yl]benzamide
Molecular weight	452.98
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	1.5
Synonyms	BDBM50142910 SCHEMBL9760072
Inchi Key	DXYSKGKXGZPWKS-AZUAARDMSA-N
Inchi ID	InChI=1S/C22H33ClN4O4/c1-30-19-13-17(24)16(23)12-15(19)22(29)25-18-6-10-26(14-20(18)31-2)11-7-21(28)27-8-4-3-5-9-27/h12-13,18,20H,3-11,14,24H2,1-2H3,(H,25,29)/t18-,20+/m0/s1
PubChem CID	67922794
ChEMBL	CHEMBL3758945
IUPHAR	N/A
BindingDB	50142910
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	1047.0 nM	PMID26761776	BindingDB
EC50	1047.13 nM	PMID26761776	ChEMBL

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