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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	G-protein coupled receptor 84
Species	Homo sapiens (Human)
Gene	GPR84
Synonym	GPCR4 GPR84 Inflammation-related G-protein coupled receptor EX33
Disease	N/A
Length	396
Amino acid sequence	MWNSSDANFSCYHESVLGYRYVAVSWGVVVAVTGTVGNVLTLLALAIQPKLRTRFNLLIANLTLADLLYCTLLQPFSVDTYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALGRYLLIAHPKLFPQVFSAKGIVLALVSTWVVGVASFAPLWPIYILVPVVCTCSFDRIRGRPYTTILMGIYFVLGLSSVGIFYCLIHRQVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQELDSRLASGGPSEGISSEPVSAATTQTLEGDSSEVGDQINSKRAKQMAEKSPPEASAKAQPIKGARRAPDSSSEFGKVTRMCFAVFLCFALSYIPFLLLNILDARVQAPRVVHMLAANLTWLNGCINPVLYAAMNRQFRQAYGSILKRGPRSFHRLH
UniProt	Q9NQS5
Protein Data Bank	N/A
GPCR-HGmod model	Q9NQS5
3D structure model	This predicted structure model is from GPCR-EXP Q9NQS5.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3714079
IUPHAR	120
DrugBank	N/A

Ligand

Name	CHEMBL3718668
Molecular formula	C24H24N2O4
IUPAC name	2-(oxolan-2-ylmethoxy)-9-phenylmethoxy-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one
Molecular weight	404.466
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	3.4
Synonyms	SCHEMBL15825893
Inchi Key	DTXHMKXGUACENM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H24N2O4/c27-24-25-23(30-16-20-7-4-12-28-20)14-22-21-9-8-19(13-18(21)10-11-26(22)24)29-15-17-5-2-1-3-6-17/h1-3,5-6,8-9,13-14,20H,4,7,10-12,15-16H2
PubChem CID	76684568
ChEMBL	CHEMBL3718668
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	0.01 nM	None	ChEMBL

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