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GPCR

NameG-protein coupled receptor 84
SpeciesHomo sapiens (Human)
GeneGPR84
SynonymGPCR4
GPR84
Inflammation-related G-protein coupled receptor EX33
DiseaseN/A
Length396
Amino acid sequenceMWNSSDANFSCYHESVLGYRYVAVSWGVVVAVTGTVGNVLTLLALAIQPKLRTRFNLLIANLTLADLLYCTLLQPFSVDTYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALGRYLLIAHPKLFPQVFSAKGIVLALVSTWVVGVASFAPLWPIYILVPVVCTCSFDRIRGRPYTTILMGIYFVLGLSSVGIFYCLIHRQVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQELDSRLASGGPSEGISSEPVSAATTQTLEGDSSEVGDQINSKRAKQMAEKSPPEASAKAQPIKGARRAPDSSSEFGKVTRMCFAVFLCFALSYIPFLLLNILDARVQAPRVVHMLAANLTWLNGCINPVLYAAMNRQFRQAYGSILKRGPRSFHRLH
UniProtQ9NQS5
Protein Data BankN/A
GPCR-HGmod modelQ9NQS5
3D structure modelThis predicted structure model is from GPCR-EXP Q9NQS5.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3714079
IUPHAR120
DrugBankN/A

Ligand

NameCHEMBL3718174
Molecular formulaC21H26N2O5
IUPAC name2-[[(2S)-1,4-dioxan-2-yl]methoxy]-9-(3-hydroxybutyl)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one
Molecular weight386.448
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP1.4
SynonymsSCHEMBL15051054
Inchi KeyDPDKIIHUMBDOHL-JRZJBTRGSA-N
Inchi IDInChI=1S/C21H26N2O5/c1-14(24)2-3-15-4-5-18-16(10-15)6-7-23-19(18)11-20(22-21(23)25)28-13-17-12-26-8-9-27-17/h4-5,10-11,14,17,24H,2-3,6-9,12-13H2,1H3/t14?,17-/m0/s1
PubChem CID89645443
ChEMBLCHEMBL3718174
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC500.01 nMNoneChEMBL
IC50101.0 nMNoneChEMBL

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