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GPCR

NameG-protein coupled receptor 6
SpeciesHomo sapiens (Human)
GeneGPR6
SynonymGPR6
Sphingosine 1-phosphate receptor GPR6
DiseaseN/A
Length362
Amino acid sequenceMNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV
UniProtP46095
Protein Data BankN/A
GPCR-HGmod modelP46095
3D structure modelThis predicted structure model is from GPCR-EXP P46095.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3714130
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3716474
Molecular formulaC25H22Cl2F3N7O2
IUPAC name3-[4-[(2,5-dichlorophenyl)methyl]piperazin-1-yl]-N-pyrazin-2-ylquinoxalin-2-amine;2,2,2-trifluoroacetic acid
Molecular weight580.393
Hydrogen bond acceptor12
Hydrogen bond donor2
XlogPNone
SynonymsN/A
Inchi KeyDKWOSYFTYHUVTO-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H21Cl2N7.C2HF3O2/c24-17-5-6-18(25)16(13-17)15-31-9-11-32(12-10-31)23-22(30-21-14-26-7-8-27-21)28-19-3-1-2-4-20(19)29-23;3-2(4,5)1(6)7/h1-8,13-14H,9-12,15H2,(H,27,28,30);(H,6,7)
PubChem CID127024763
ChEMBLCHEMBL3716474
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
IC502340.0 nMNoneChEMBL

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