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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	G-protein coupled receptor 84
Species	Homo sapiens (Human)
Gene	GPR84
Synonym	GPCR4 GPR84 Inflammation-related G-protein coupled receptor EX33
Disease	N/A
Length	396
Amino acid sequence	MWNSSDANFSCYHESVLGYRYVAVSWGVVVAVTGTVGNVLTLLALAIQPKLRTRFNLLIANLTLADLLYCTLLQPFSVDTYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALGRYLLIAHPKLFPQVFSAKGIVLALVSTWVVGVASFAPLWPIYILVPVVCTCSFDRIRGRPYTTILMGIYFVLGLSSVGIFYCLIHRQVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQELDSRLASGGPSEGISSEPVSAATTQTLEGDSSEVGDQINSKRAKQMAEKSPPEASAKAQPIKGARRAPDSSSEFGKVTRMCFAVFLCFALSYIPFLLLNILDARVQAPRVVHMLAANLTWLNGCINPVLYAAMNRQFRQAYGSILKRGPRSFHRLH
UniProt	Q9NQS5
Protein Data Bank	N/A
GPCR-HGmod model	Q9NQS5
3D structure model	This predicted structure model is from GPCR-EXP Q9NQS5.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3714079
IUPHAR	120
DrugBank	N/A

Ligand

Name	CHEMBL3715368
Molecular formula	C24H24N2O4
IUPAC name	9-(2-methoxyphenyl)-2-(oxolan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one
Molecular weight	404.466
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	3.5
Synonyms	SCHEMBL15825846
Inchi Key	CRRUEYNUXMNJJM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H24N2O4/c1-28-22-7-3-2-6-20(22)16-8-9-19-17(13-16)10-11-26-21(19)14-23(25-24(26)27)30-15-18-5-4-12-29-18/h2-3,6-9,13-14,18H,4-5,10-12,15H2,1H3
PubChem CID	76684672
ChEMBL	CHEMBL3715368
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	100.0 nM	None	ChEMBL

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