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GPCR

NameG-protein coupled receptor 6
SpeciesHomo sapiens (Human)
GeneGPR6
SynonymGPR6
Sphingosine 1-phosphate receptor GPR6
DiseaseN/A
Length362
Amino acid sequenceMNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV
UniProtP46095
Protein Data BankN/A
GPCR-HGmod modelP46095
3D structure modelThis predicted structure model is from GPCR-EXP P46095.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3714130
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3716757
Molecular formulaC24H25F6N5O2
IUPAC name2-[4-[(2,4-difluorophenyl)-fluoromethyl]piperidin-1-yl]-N-propan-2-ylpyrido[3,4-b]pyrazin-3-amine;2,2,2-trifluoroacetic acid
Molecular weight529.487
Hydrogen bond acceptor13
Hydrogen bond donor2
XlogPNone
SynonymsN/A
Inchi KeyCPIKVJAYXCISOW-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H24F3N5.C2HF3O2/c1-13(2)27-21-22(29-18-5-8-26-12-19(18)28-21)30-9-6-14(7-10-30)20(25)16-4-3-15(23)11-17(16)24;3-2(4,5)1(6)7/h3-5,8,11-14,20H,6-7,9-10H2,1-2H3,(H,27,28);(H,6,7)
PubChem CID127024696
ChEMBLCHEMBL3716757
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
IC5029.0 nMNoneChEMBL

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