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GPCR

NameG-protein coupled receptor 6
SpeciesHomo sapiens (Human)
GeneGPR6
SynonymGPR6
Sphingosine 1-phosphate receptor GPR6
DiseaseN/A
Length362
Amino acid sequenceMNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV
UniProtP46095
Protein Data BankN/A
GPCR-HGmod modelP46095
3D structure modelThis predicted structure model is from GPCR-EXP P46095.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3714130
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3718669
Molecular formulaC24H26Cl2F3N5O2
IUPAC name3-[4-[(2,5-dichlorophenyl)methyl]piperazin-1-yl]-N-propan-2-ylquinoxalin-2-amine;2,2,2-trifluoroacetic acid
Molecular weight544.4
Hydrogen bond acceptor10
Hydrogen bond donor2
XlogPNone
SynonymsN/A
Inchi KeyCNQDVRIDPCQPHJ-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H25Cl2N5.C2HF3O2/c1-15(2)25-21-22(27-20-6-4-3-5-19(20)26-21)29-11-9-28(10-12-29)14-16-13-17(23)7-8-18(16)24;3-2(4,5)1(6)7/h3-8,13,15H,9-12,14H2,1-2H3,(H,25,26);(H,6,7)
PubChem CID127024820
ChEMBLCHEMBL3718669
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
IC503310.0 nMNoneChEMBL

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