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GPCR

NameG-protein coupled receptor 84
SpeciesHomo sapiens (Human)
GeneGPR84
SynonymGPCR4
GPR84
Inflammation-related G-protein coupled receptor EX33
DiseaseN/A
Length396
Amino acid sequenceMWNSSDANFSCYHESVLGYRYVAVSWGVVVAVTGTVGNVLTLLALAIQPKLRTRFNLLIANLTLADLLYCTLLQPFSVDTYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALGRYLLIAHPKLFPQVFSAKGIVLALVSTWVVGVASFAPLWPIYILVPVVCTCSFDRIRGRPYTTILMGIYFVLGLSSVGIFYCLIHRQVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQELDSRLASGGPSEGISSEPVSAATTQTLEGDSSEVGDQINSKRAKQMAEKSPPEASAKAQPIKGARRAPDSSSEFGKVTRMCFAVFLCFALSYIPFLLLNILDARVQAPRVVHMLAANLTWLNGCINPVLYAAMNRQFRQAYGSILKRGPRSFHRLH
UniProtQ9NQS5
Protein Data BankN/A
GPCR-HGmod modelQ9NQS5
3D structure modelThis predicted structure model is from GPCR-EXP Q9NQS5.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3714079
IUPHAR120
DrugBankN/A

Ligand

NameCHEMBL3828033
Molecular formulaC10H14N2O2S
IUPAC name2-[(Z)-hex-3-enyl]sulfanyl-4-hydroxy-1H-pyrimidin-6-one
Molecular weight226.294
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP1.8
SynonymsBDBM50189540
Inchi KeyCBLJETOONBDEQN-ARJAWSKDSA-N
Inchi IDInChI=1S/C10H14N2O2S/c1-2-3-4-5-6-15-10-11-8(13)7-9(14)12-10/h3-4,7H,2,5-6H2,1H3,(H2,11,12,13,14)/b4-3-
PubChem CID127045481
ChEMBLCHEMBL3828033
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
%max69.3 %PMID27326330ChEMBL
EC50938.0 nMPMID27326330ChEMBL

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