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Name | Metabotropic glutamate receptor 1 |
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Species | Homo sapiens (Human) |
Gene | GRM1 |
Synonym | SCAR13 MGLUR1 mGlu1 receptor metabotropic glutamate receptor 1 GPRC1A [ Show all ] |
Disease | Alzheimer disease; Huntington's disease Neurological disease Neuropathic pain Schizophrenia Pain |
Length | 1194 |
Amino acid sequence | MVGLLLFFFPAIFLEVSLLPRSPGRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGINRCLPDGQSLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKRICTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFLIKSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKIQMNKSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEYVQDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKAGAGNANSNGKSVSWSEPGGGQVPKGQHMWHRLSVHVKTNETACNQTAVIKPLTKSYQGSGKSLTFSDTSTKTLYNVEEEEDAQPIRFSPPGSPSMVVHRRVPSAATTPPLPSHLTAEETPLFLAEPALPKGLPPPLQQQQQPPPQQKSLMDQLQGVVSNFSTAIPDFHAVLAGPGGPGNGLRSLYPPPPPPQHLQMLPLQLSTFGEELVSPPADDDDDSERFKLLQEYVYEHEREGNTEEDELEEEEEDLQAASKLTPDDSPALTPPSPFRDSVASGSSVPSSPVSESVLCTPPNVSYASVILRDYKQSSSTL |
UniProt | Q13255 |
Protein Data Bank | 4or2, 3ks9 |
GPCR-HGmod model | N/A |
3D structure model | This structure is from PDB ID 4or2. |
BioLiP | BL0271871,BL0271876, BL0271872,BL0271873,BL0271874,, BL0174211,BL0174213, BL0174210,BL0174212 |
Therapeutic Target Database | T27137 |
ChEMBL | CHEMBL3772 |
IUPHAR | 289 |
DrugBank | BE0000824 |
Name | CHEMBL3787296 |
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Molecular formula | C19H13Cl2N3O2S |
IUPAC name | N-[3-chloro-4-(4-chloro-3-oxo-1H-isoindol-2-yl)phenyl]-5-methyl-1,3-thiazole-4-carboxamide |
Molecular weight | 418.292 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 1 |
XlogP | 4.4 |
Synonyms | BDBM50159559 |
Inchi Key | BVURCENMQQMGOC-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C19H13Cl2N3O2S/c1-10-17(22-9-27-10)18(25)23-12-5-6-15(14(21)7-12)24-8-11-3-2-4-13(20)16(11)19(24)26/h2-7,9H,8H2,1H3,(H,23,25) |
PubChem CID | 127033435 |
ChEMBL | CHEMBL3787296 |
IUPHAR | N/A |
BindingDB | 50159559 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
%max | 69.0 % | PMID26988302 | ChEMBL |
EC50 | 4690.0 nM | PMID26988302 | BindingDB,ChEMBL |
EC50 | 4786.0 nM | PMID26988302 | BindingDB |
EC50 | 4786.3 nM | PMID26988302 | ChEMBL |
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