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GPCR

NameG-protein coupled receptor 6
SpeciesHomo sapiens (Human)
GeneGPR6
SynonymGPR6
Sphingosine 1-phosphate receptor GPR6
DiseaseN/A
Length362
Amino acid sequenceMNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV
UniProtP46095
Protein Data BankN/A
GPCR-HGmod modelP46095
3D structure modelThis predicted structure model is from GPCR-EXP P46095.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3714130
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3714945
Molecular formulaC24H25F4N5O4
IUPAC nameN-cyclopropyl-2-[4-(2-fluoro-4-methoxyphenoxy)piperidin-1-yl]pyrido[3,4-b]pyrazin-3-amine;2,2,2-trifluoroacetic acid
Molecular weight523.489
Hydrogen bond acceptor13
Hydrogen bond donor2
XlogPNone
SynonymsN/A
Inchi KeyBGAHYUSAPSQFRD-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H24FN5O2.C2HF3O2/c1-29-16-4-5-20(17(23)12-16)30-15-7-10-28(11-8-15)22-21(25-14-2-3-14)26-19-13-24-9-6-18(19)27-22;3-2(4,5)1(6)7/h4-6,9,12-15H,2-3,7-8,10-11H2,1H3,(H,25,26);(H,6,7)
PubChem CID127024604
ChEMBLCHEMBL3714945
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
IC5044.0 nMNoneChEMBL

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