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GPCR

Name	Alpha-2C adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA2C
Synonym	alpha2-C4 Adra-2c ADRA2L2 ADRA2RL2 Adrenergic alpha2C- receptor class I adrenergic receptor alpha-2 adrenergic receptor subtype C4 alpha2C-adrenoceptor alpha-2C adrenergic receptor Alpha-2C adrenoceptor alpha-2C adrenoreceptor Alpha-2CAR [ Show all ]
Disease	Diabetic nephropathy; Fibromyalgia Hypertension Heart failure Glaucoma Alzheimer disease Asthma Erythema Contusion Depression Hypotension Male sexual disorders Neurological disease Obesity Ocular disease Allergic rhinitis Alcohol use disorders Ocular hypertension Poison intoxication Peptic ulcer Pain [ Show all ]
Length	462
Amino acid sequence	MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
UniProt	P18825
Protein Data Bank	N/A
GPCR-HGmod model	P18825
3D structure model	This predicted structure model is from GPCR-EXP P18825.
BioLiP	N/A
Therapeutic Target Database	T01777
ChEMBL	CHEMBL1916
IUPHAR	27
DrugBank	BE0004864, BE0000342, BE0004888

Ligand

Name	propranolol
Molecular formula	C16H21NO2
IUPAC name	1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol
Molecular weight	259.349
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	3.0
Synonyms	propranololo Dociton 2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)- (9CI) Reducor Euprovasin 3-[(methylethyl)amino]-1-naphthyloxypropan-2-ol SPBio_001658 ICI 45520 (Salt/Mix) AB0108847 Spectrum5_000751 Inderol AN-45556 KBio3_001902 AY 64043 L000679 NSC 91523 (Salt/Mix) Beta-Tablinen NCGC00015798-05 PDSP1_001608 BPBio1_001040 (+/-)-Propranolol-D7 (ring-D7) solution, 100 mug/mL in methanol with 5% 1 M HCl, ampule of 1 mL, certified reference material Prestwick3_000952 CBDivE_006180 1-((1-Methylethyl)amino)-3-(1-naphthalenyloxy)-2-propanol CTK8I6896 1-(Isopropylamino)-3-(naphthalen-1-yloxy)propan-2-ol 1-Isopropylamino-3-(1-naphthyloxy)-2-propanol Propranololum [INN-Latin] Efektolol 2-Propanol, 1-(isopropylamino)-3-(1-naphthyloxy)- SBI-0050871.P003 FT-0700657 Spectrum2_001699 Inderal (Salt/Mix) AC1Q1QC0 Sumial KBio1_000023 AQHHHDLHHXJYJD-UHFFFAOYSA-N KBioGR_001684 NCGC00015798-08 BBL023437 LS-184129 Obsidan (Salt/Mix) Betadren PDSP2_001592 BSPBio_000944 (A+/-)-Propranolol hydrochloride Propanolol CHEBI:8499 1-(alpha-naphthoxy)-3-(iso-propylamino)-2-propanol Propranolol Hcl Intensol dl-propranolol 13013-17-7 Racemic propranolol EN300-40731 Servanolol HMS2090L21 AB00053537_11 Spectrum4_000974 INDERIDE-40/25 ALBB-023324 [2-hydroxy-3-(naphthalen-1-yloxy)propyl](propan-2-yl)amine KBio2_007651 Avlocardyl (Salt/Mix) Kemi S NCGC00024690-03 Berkolol MolPort-001-794-623 PDSP1_000767 Bio1_000856 Prestwick1_000952 C16H21NO2 .beta.-Propranolol Propanolol,(+/-) cMAP_000071 1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol PROPRANOLOL,(+) Propranololo [DCIT] Dociton (Salt/Mix) 2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-, (+-)- Reducor line F0001-3681 525-66-6 SPBio_003093 IDI1_000023 AC1L1JA4 ST024757 Intermigran Anaprilin KBio3_002993 AY-20694 Lopac0_000896 NSC91523 Beta-Timelets NCGC00015798-06 PDSP2_000755 BRD-A10070317-003-06-9 (.+/-.)-Propranolol Propanalol CCG-103643 1-((1-Methylethyl)amino)-3-(1-naphthyloxy)-2-propanol Propranolol (INN) D,L-Propranolol 1-(isopropylamino)-3-naphthalen-1-yloxy-propan-2-ol 1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol Proprasylyt EINECS 208-378-0 2-Propanol, 1-(isopropylamino)-3-(1-naphthyloxy)-, (+-)- SCHEMBL12264958 GTPL564 AB00053537 Spectrum3_000883 Inderal hydrochloride AKOS000588816 T7896 KBio2_002515 ARONIS27011 KBioGR_002515 NCGC00015798-09 BDBM25761 MCULE-7804628650 Obzidan Betalong Pranolol BSPBio_002682 (S)-(-)-PROPRANOLOL Propanolol [INN-Spanish] 1-(alpha-naphthoxy)-3-(isopropylamino)-2-propanol Propranolol [INN:BAN] DB00571 PROPRANOLOL,(-) DL-Propranolol hydrochloride 2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)- racemic-Propranolol etalong 3-(naphthalen-1-yloxy)-1-(propan-2-ylamino)propan-2-ol SPBio_001361 HMS3428G03 AB00053537_12 Spectrum4_001222 INDERIDE-80/25 AN-18866 KBio3_001766 AY 20694 KS-00002WT3 NINDS_000023 beta-Propranolol NCGC00015798-04 PDSP1_001607 Bio1_001345 (+-)-Propranolol Prestwick2_000952 Caridolol 1(-alpha-naphthoxy)-3-(iso-propylamino)-2-propanol Propranalol Corpendol 1-(isopropylamino)-3-(1-naphthyloxy)propan-2-ol Propranololum DTXSID6023525 2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-, (+-)- (9CI) Sawatal FE-0204 525P666 Spectrum2_001301 Inderal AC1Q1QBV STK735510 KB-123971 Anapriline KBioGR_001347 NCGC00015798-07 b-Propranolol LS-122410 Obsidan Betachron PDSP2_001591 BRD-A10070317-003-17-6 (1)-1-(Isopropylamino)-3-(naphthyloxy)propan-2-ol Propanix CCRIS 3082 1-(1-Naphthyloxy)-2-hydroxy-3-(isopropylamino)propane Propranolol (TN) D08443 1-(naphthalen-1-yloxy)-3-(propan-2-ylamino)propan-2-ol 1-[(1-methylethyl)amino]-3-(naphthalen-1-yloxy)propan-2-ol R,S-Propranolol Hydrochloride EINECS 235-867-6 2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)- SCHEMBL3955 hemangiol AB00053537-10 Spectrum3_001071 Inderex AKOS016050338 W-109550 KBio2_005083 Avlocardyl KBioSS_002523 NCGC00024690-02 Bedranol Migrastat Oprea1_304193 Bio1_000367 Prestwick0_000952 C07407 PROPANOLOL(-) CHEMBL27 1-(Isopropylamino)-3-(1-naphthoxy)-propan-2-ol PROPRANOLOL, d DivK1c_000023 [ Show all ]
Inchi Key	AQHHHDLHHXJYJD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3
PubChem CID	4946
ChEMBL	CHEMBL27
IUPHAR	564
BindingDB	25761
DrugBank	DB00571
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<5011.87 nM	PMID26565745	ChEMBL
IC50	<5011.87 nM	PMID26565745	ChEMBL

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