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GPCR

Name	Muscarinic acetylcholine receptor M2
Species	Homo sapiens (Human)
Gene	CHRM2
Synonym	cholinergic receptor AChR M2 M2 muscarinic acetylcholine receptor M2 receptor Chrm-2 cholinergic receptor, muscarinic 2, cardiac cholinergic receptor, muscarinic 2 [ Show all ]
Disease	Urinary incontinence Heart failure Nausea; Addiction Parkinson's disease Peptic ulcer Stabilize muscle contractions Unspecified Cardiovascular disorder Asthma Alzheimer disease [ Show all ]
Length	466
Amino acid sequence	MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
UniProt	P08172
Protein Data Bank	5zkc, 4mqs, 4mqt, 5yc8, 5zk3, 5zkb, 5zk8
GPCR-HGmod model	P08172
3D structure model	This structure is from PDB ID 5zkc.
BioLiP	BL0433341, BL0433216, BL0263147, BL0263146, BL0263145, BL0433339, BL0433340, BL0433338
Therapeutic Target Database	T46185
ChEMBL	CHEMBL211
IUPHAR	14
DrugBank	BE0000560

Ligand

Name	propranolol
Molecular formula	C16H21NO2
IUPAC name	1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol
Molecular weight	259.349
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	3.0
Synonyms	Obsidan PDSP2_001591 Propanix Propranolol (TN) Propranololum Sawatal Spectrum2_001301 STK735510 NCGC00015798-07 EINECS 235-867-6 2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)- hemangiol AB00053537-10 Inderex AKOS016050338 KBio2_005083 Avlocardyl KBioSS_002523 Bedranol Migrastat Bio1_000367 C07407 CHEMBL27 1-(Isopropylamino)-3-(1-naphthoxy)-propan-2-ol DivK1c_000023 1-[(1-methylethyl)amino]-3-(naphthalen-1-yloxy)propan-2-ol Oprea1_304193 Prestwick0_000952 PROPANOLOL(-) PROPRANOLOL, d R,S-Propranolol Hydrochloride SCHEMBL3955 Spectrum3_001071 W-109550 NCGC00024690-02 Euprovasin 3-[(methylethyl)amino]-1-naphthyloxypropan-2-ol ICI 45520 (Salt/Mix) AB0108847 Inderol AN-45556 KBio3_001902 AY 64043 L000679 Beta-Tablinen NCGC00015798-05 BPBio1_001040 (+/-)-Propranolol-D7 (ring-D7) solution, 100 mug/mL in methanol with 5% 1 M HCl, ampule of 1 mL, certified reference material CBDivE_006180 1-((1-Methylethyl)amino)-3-(1-naphthalenyloxy)-2-propanol CTK8I6896 1-(Isopropylamino)-3-(naphthalen-1-yloxy)propan-2-ol Dociton 2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)- (9CI) NSC 91523 (Salt/Mix) PDSP1_001608 Prestwick3_000952 propranololo Reducor SPBio_001658 Spectrum5_000751 2-Propanol, 1-(isopropylamino)-3-(1-naphthyloxy)- FT-0700657 Inderal (Salt/Mix) AC1Q1QC0 KBio1_000023 AQHHHDLHHXJYJD-UHFFFAOYSA-N KBioGR_001684 BBL023437 LS-184129 Betadren BSPBio_000944 (A+/-)-Propranolol hydrochloride CHEBI:8499 1-(alpha-naphthoxy)-3-(iso-propylamino)-2-propanol 1-Isopropylamino-3-(1-naphthyloxy)-2-propanol Efektolol Obsidan (Salt/Mix) PDSP2_001592 Propanolol Propranolol Hcl Intensol Propranololum [INN-Latin] SBI-0050871.P003 Spectrum2_001699 Sumial NCGC00015798-08 EN300-40731 HMS2090L21 AB00053537_11 INDERIDE-40/25 ALBB-023324 KBio2_007651 Avlocardyl (Salt/Mix) Kemi S Berkolol MolPort-001-794-623 Bio1_000856 C16H21NO2 .beta.-Propranolol cMAP_000071 1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol dl-propranolol 13013-17-7 PDSP1_000767 Prestwick1_000952 Propanolol,(+/-) PROPRANOLOL,(+) Racemic propranolol Servanolol Spectrum4_000974 [2-hydroxy-3-(naphthalen-1-yloxy)propyl](propan-2-yl)amine NCGC00024690-03 2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-, (+-)- F0001-3681 525-66-6 IDI1_000023 AC1L1JA4 Intermigran Anaprilin KBio3_002993 AY-20694 Lopac0_000896 Beta-Timelets NCGC00015798-06 BRD-A10070317-003-06-9 (.+/-.)-Propranolol CCG-103643 1-((1-Methylethyl)amino)-3-(1-naphthyloxy)-2-propanol D,L-Propranolol 1-(isopropylamino)-3-naphthalen-1-yloxy-propan-2-ol Dociton (Salt/Mix) NSC91523 PDSP2_000755 Propanalol Propranolol (INN) Propranololo [DCIT] Reducor line SPBio_003093 ST024757 2-Propanol, 1-(isopropylamino)-3-(1-naphthyloxy)-, (+-)- GTPL564 AB00053537 Inderal hydrochloride AKOS000588816 KBio2_002515 ARONIS27011 KBioGR_002515 BDBM25761 MCULE-7804628650 Betalong BSPBio_002682 (S)-(-)-PROPRANOLOL 1-(alpha-naphthoxy)-3-(isopropylamino)-2-propanol DB00571 1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol EINECS 208-378-0 Obzidan Pranolol Propanolol [INN-Spanish] Propranolol [INN:BAN] Proprasylyt SCHEMBL12264958 Spectrum3_000883 T7896 NCGC00015798-09 etalong 3-(naphthalen-1-yloxy)-1-(propan-2-ylamino)propan-2-ol HMS3428G03 AB00053537_12 INDERIDE-80/25 AN-18866 KBio3_001766 AY 20694 KS-00002WT3 beta-Propranolol NCGC00015798-04 Bio1_001345 (+-)-Propranolol Caridolol 1(-alpha-naphthoxy)-3-(iso-propylamino)-2-propanol Corpendol 1-(isopropylamino)-3-(1-naphthyloxy)propan-2-ol DL-Propranolol hydrochloride 2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)- PDSP1_001607 Prestwick2_000952 Propranalol PROPRANOLOL,(-) racemic-Propranolol SPBio_001361 Spectrum4_001222 NINDS_000023 2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-, (+-)- (9CI) FE-0204 525P666 Inderal AC1Q1QBV KB-123971 Anapriline KBioGR_001347 b-Propranolol LS-122410 Betachron BRD-A10070317-003-17-6 (1)-1-(Isopropylamino)-3-(naphthyloxy)propan-2-ol CCRIS 3082 1-(1-Naphthyloxy)-2-hydroxy-3-(isopropylamino)propane D08443 1-(naphthalen-1-yloxy)-3-(propan-2-ylamino)propan-2-ol DTXSID6023525 [ Show all ]
Inchi Key	AQHHHDLHHXJYJD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3
PubChem CID	4946
ChEMBL	CHEMBL27
IUPHAR	564
BindingDB	25761
DrugBank	DB00571
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<5011.87 nM	PMID26565745	ChEMBL
IC50	<5011.87 nM	PMID26565745	ChEMBL

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