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GPCR

NameFree fatty acid receptor 1
SpeciesHomo sapiens (Human)
GeneFFAR1
SynonymFFA1R
G protein-coupled receptor 40
G-protein coupled receptor 40
GPR40
FFA1 receptor
DiseaseType 2 diabetes
Non-insulin dependent diabetes
Diabetes
Length300
Amino acid sequenceMDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
UniProtO14842
Protein Data Bank5tzy, 5tzr
GPCR-HGmod modelO14842
3D structure modelThis structure is from PDB ID 5tzy.
BioLiPBL0380462, BL0380463, BL0380464
Therapeutic Target DatabaseT25608
ChEMBLCHEMBL4422
IUPHAR225
DrugBankBE0000688

Ligand

NameCHEMBL3780505
Molecular formulaC20H17NO5
IUPAC name2-[6-[(5-phenyl-1,3-oxazol-2-yl)methoxy]-2,3-dihydro-1-benzofuran-3-yl]acetic acid
Molecular weight351.358
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP2.8
SynonymsN/A
Inchi KeyACIPEPWXUJKTQO-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H17NO5/c22-20(23)8-14-11-25-17-9-15(6-7-16(14)17)24-12-19-21-10-18(26-19)13-4-2-1-3-5-13/h1-7,9-10,14H,8,11-12H2,(H,22,23)
PubChem CID127032237
ChEMBLCHEMBL3780505
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Activity2.34 %PMID26945112ChEMBL
Activity10.15 %PMID26945112ChEMBL

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