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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Taste receptor type 2 member 14
Species	Homo sapiens (Human)
Gene	TAS2R14
Synonym	T2R14 TAS2R14 Taste receptor family B member 1 taste receptor, type 2, member 14 TRB1
Disease	N/A
Length	317
Amino acid sequence	MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
UniProt	Q9NYV8
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYV8
3D structure model	This predicted structure model is from GPCR-EXP Q9NYV8.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3309105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1278819
Molecular formula	C20H19NO6S
IUPAC name	4-[furan-2-ylmethyl-[(2-methoxyphenyl)methyl]sulfamoyl]benzoic acid
Molecular weight	401.433
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	2.7
Synonyms	UOCGGLUFMCGMCT-UHFFFAOYSA-N 4-(N-(furan-2-ylmethyl)-N-(2-methoxybenzyl)sulfamoyl)benzoic acid CHEMBL3923737 US9247759, 5-7 BDBM211086
Inchi Key	UOCGGLUFMCGMCT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H19NO6S/c1-26-19-7-3-2-5-16(19)13-21(14-17-6-4-12-27-17)28(24,25)18-10-8-15(9-11-18)20(22)23/h2-12H,13-14H2,1H3,(H,22,23)
PubChem CID	57944927
ChEMBL	CHEMBL3923737
IUPHAR	N/A
BindingDB	211086
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	12000.0 nM	N/A	BindingDB
IC50	12000.0 nM	None	ChEMBL

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