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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Taste receptor type 2 member 14
Species	Homo sapiens (Human)
Gene	TAS2R14
Synonym	T2R14 TAS2R14 Taste receptor family B member 1 taste receptor, type 2, member 14 TRB1
Disease	N/A
Length	317
Amino acid sequence	MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
UniProt	Q9NYV8
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYV8
3D structure model	This predicted structure model is from GPCR-EXP Q9NYV8.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3309105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	4-Diisobutylsulfamoyl-benzoic acid
Molecular formula	C15H23NO4S
IUPAC name	4-[bis(2-methylpropyl)sulfamoyl]benzoic acid
Molecular weight	313.412
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	4.1
Synonyms	Benzoic acid,4-[[bis(2-methylpropyl)amino]sulfonyl]- HMS1587L19 US9247759, 5-9 4-[bis(2-methylpropyl)sulfamoyl]benzoic acid AC1LDOFC CHEMBL3954532 Oprea1_225951 10252-81-0 BDBM211088 EN300-00391 ST032337 4-[(Diisobutylamino)sulfonyl]benzoic acid Cambridge id 6940603 MCULE-2712337744 Z56786624 4-{[bis(2-methylpropyl)amino]sulfonyl}benzoic acid AC1Q1PJQ CTK4A1172 SBMWIDCANKNKIX-UHFFFAOYSA-N Benzoic acid, 4-[4-di(2-methylpropyl)aminosulfonyl]- EU-0052539 STK676627 4-[(Diisobutylamino)sulfonyl]benzoic acid # MolPort-002-228-378 ZINC36826 A2286/0096266 AKOS000121841 DTXSID50347553 SCHEMBL1278936 [ Show all ]
Inchi Key	SBMWIDCANKNKIX-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H23NO4S/c1-11(2)9-16(10-12(3)4)21(19,20)14-7-5-13(6-8-14)15(17)18/h5-8,11-12H,9-10H2,1-4H3,(H,17,18)
PubChem CID	622959
ChEMBL	CHEMBL3954532
IUPHAR	N/A
BindingDB	211088
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	15000.0 nM	N/A	BindingDB
IC50	15000.0 nM	None	ChEMBL

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