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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Taste receptor type 2 member 14
Species	Homo sapiens (Human)
Gene	TAS2R14
Synonym	T2R14 TAS2R14 Taste receptor family B member 1 taste receptor, type 2, member 14 TRB1
Disease	N/A
Length	317
Amino acid sequence	MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
UniProt	Q9NYV8
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYV8
3D structure model	This predicted structure model is from GPCR-EXP Q9NYV8.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3309105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1278774
Molecular formula	C22H18N2O4S
IUPAC name	4-[benzyl-[(4-cyanophenyl)methyl]sulfamoyl]benzoic acid
Molecular weight	406.456
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	3.3
Synonyms	US9247759, 5-146 CHEMBL3962098 US9247759, 5-91 BDBM211152
Inchi Key	OMEHUFNVMNYKJR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H18N2O4S/c23-14-17-6-8-19(9-7-17)16-24(15-18-4-2-1-3-5-18)29(27,28)21-12-10-20(11-13-21)22(25)26/h1-13H,15-16H2,(H,25,26)
PubChem CID	57422382
ChEMBL	CHEMBL3962098
IUPHAR	N/A
BindingDB	211152
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1848.0 nM	None	ChEMBL
IC50	1848.0 nM	N/A	BindingDB

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