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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Taste receptor type 2 member 14
Species	Homo sapiens (Human)
Gene	TAS2R14
Synonym	T2R14 TAS2R14 Taste receptor family B member 1 taste receptor, type 2, member 14 TRB1
Disease	N/A
Length	317
Amino acid sequence	MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
UniProt	Q9NYV8
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYV8
3D structure model	This predicted structure model is from GPCR-EXP Q9NYV8.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3309105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1615156
Molecular formula	C16H13ClFN3O4S
IUPAC name	N-(4-chloro-2-fluorophenyl)-1,3-dimethyl-2,4-dioxoquinazoline-6-sulfonamide
Molecular weight	397.805
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	2.1
Synonyms	CHEMBL3938203
Inchi Key	NZWZGVKNALWCSR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H13ClFN3O4S/c1-20-14-6-4-10(8-11(14)15(22)21(2)16(20)23)26(24,25)19-13-5-3-9(17)7-12(13)18/h3-8,19H,1-2H3
PubChem CID	57944921
ChEMBL	CHEMBL3938203
IUPHAR	N/A
BindingDB	211236
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	9703.0 nM	None	ChEMBL
IC50	9703.0 nM	N/A	BindingDB

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