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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Taste receptor type 2 member 14
Species	Homo sapiens (Human)
Gene	TAS2R14
Synonym	T2R14 TAS2R14 Taste receptor family B member 1 taste receptor, type 2, member 14 TRB1
Disease	N/A
Length	317
Amino acid sequence	MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
UniProt	Q9NYV8
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYV8
3D structure model	This predicted structure model is from GPCR-EXP Q9NYV8.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3309105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	Oprea1_594647
Molecular formula	C23H28ClNO4S
IUPAC name	ethyl 4-[[benzyl-(4-chlorophenyl)sulfonylamino]methyl]cyclohexane-1-carboxylate
Molecular weight	449.99
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	4.9
Synonyms	ethyl 4-({benzyl[(4-chlorophenyl)sulfonyl]amino}methyl)cyclohexanecarboxylate SR-01000579850-1 MolPort-007-926-085 SCHEMBL1615052 HMS1912D04 US9247759, 5-119 NCGC00139290-01 AKOS002126496 CHEMBL1356858 SR-01000579850 K783-1141 ZINC8583120 BDBM211173 [ Show all ]
Inchi Key	GBMWNGYMHVXNDH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H28ClNO4S/c1-2-29-23(26)20-10-8-19(9-11-20)17-25(16-18-6-4-3-5-7-18)30(27,28)22-14-12-21(24)13-15-22/h3-7,12-15,19-20H,2,8-11,16-17H2,1H3
PubChem CID	16034015
ChEMBL	CHEMBL1356858
IUPHAR	N/A
BindingDB	211173
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	672.0 nM	N/A	BindingDB
IC50	672.0 nM	None	ChEMBL

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