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GPCR

NameTaste receptor type 2 member 8
SpeciesHomo sapiens (Human)
GeneTAS2R8
SynonymT2R8
TAS2R8
Taste receptor family B member 5
taste receptor, type 2, member 8
TRB5
DiseaseN/A
Length309
Amino acid sequenceMFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLISVMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFLWLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYFEPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSFIFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRMLTCRKIACMI
UniProtQ9NYW2
Protein Data BankN/A
GPCR-HGmod modelQ9NYW2
3D structure modelThis predicted structure model is from GPCR-EXP Q9NYW2.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3988599
IUPHARN/A
DrugBankN/A

Ligand

NameSCHEMBL1279600
Molecular formulaC20H20ClN5O3
IUPAC name1-[2-(2-chlorophenyl)ethyl]-3-[1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]pyrazol-4-yl]imidazolidine-2,4-dione
Molecular weight413.862
Hydrogen bond acceptor5
Hydrogen bond donor0
XlogP2.6
SynonymsCHEMBL3919276
US9247759, 10-81
BDBM211333
FBVPFIGLPMQKHI-UHFFFAOYSA-N
1-(2-chlorophenethyl)-3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)imidazolidine-2,4-dione
Inchi KeyFBVPFIGLPMQKHI-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H20ClN5O3/c1-13-17(14(2)29-23-13)11-25-10-16(9-22-25)26-19(27)12-24(20(26)28)8-7-15-5-3-4-6-18(15)21/h3-6,9-10H,7-8,11-12H2,1-2H3
PubChem CID57944977
ChEMBLCHEMBL3919276
IUPHARN/A
BindingDB211333
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50250.0 nMN/ABindingDB
IC50250.0 nMNoneChEMBL

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