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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Taste receptor type 2 member 8
Species	Homo sapiens (Human)
Gene	TAS2R8
Synonym	T2R8 TAS2R8 Taste receptor family B member 5 taste receptor, type 2, member 8 TRB5
Disease	N/A
Length	309
Amino acid sequence	MFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLISVMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFLWLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYFEPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSFIFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRMLTCRKIACMI
UniProt	Q9NYW2
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYW2
3D structure model	This predicted structure model is from GPCR-EXP Q9NYW2.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3988599
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1278714
Molecular formula	C19H18FN5O3
IUPAC name	3-[1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]pyrazol-4-yl]-1-[(2-fluorophenyl)methyl]imidazolidine-2,4-dione
Molecular weight	383.383
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	1.6
Synonyms	3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-1-(2-fluorobenzyl)imidazolidine-2,4-dione CHEMBL3965292 US9247759, 10-21 BDBM211273 DHTBKZDXNSKLRT-UHFFFAOYSA-N
Inchi Key	DHTBKZDXNSKLRT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H18FN5O3/c1-12-16(13(2)28-22-12)10-24-9-15(7-21-24)25-18(26)11-23(19(25)27)8-14-5-3-4-6-17(14)20/h3-7,9H,8,10-11H2,1-2H3
PubChem CID	57422443
ChEMBL	CHEMBL3965292
IUPHAR	N/A
BindingDB	211273
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	80.0 nM	N/A	BindingDB
IC50	80.0 nM	None	ChEMBL

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