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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Taste receptor type 2 member 14
Species	Homo sapiens (Human)
Gene	TAS2R14
Synonym	T2R14 TAS2R14 Taste receptor family B member 1 taste receptor, type 2, member 14 TRB1
Disease	N/A
Length	317
Amino acid sequence	MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
UniProt	Q9NYV8
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYV8
3D structure model	This predicted structure model is from GPCR-EXP Q9NYV8.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3309105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1279268
Molecular formula	C22H27NO4S
IUPAC name	4-[[benzyl-(4-methylphenyl)sulfonylamino]methyl]cyclohexane-1-carboxylic acid
Molecular weight	401.521
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	3.9
Synonyms	US9247759, 5-11 AWXNGVLQQNVMNB-UHFFFAOYSA-N CHEMBL3895068 4-((N-benzyl-4-methylphenylsulfonamido) methyl)cyclohexanecarboxylic acid BDBM211090 4-((N-benzyl-4-methylphenylsulfonamido)methyl)cyclohexanecarboxylic acid [ Show all ]
Inchi Key	AWXNGVLQQNVMNB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H27NO4S/c1-17-7-13-21(14-8-17)28(26,27)23(15-18-5-3-2-4-6-18)16-19-9-11-20(12-10-19)22(24)25/h2-8,13-14,19-20H,9-12,15-16H2,1H3,(H,24,25)
PubChem CID	25205358
ChEMBL	CHEMBL3895068
IUPHAR	N/A
BindingDB	211090
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	14.0 nM	None	ChEMBL
IC50	14.0 nM	N/A	BindingDB

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