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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Prostaglandin E2 receptor EP1 subtype
Species	Mus musculus (Mouse)
Gene	Ptger1
Synonym	EP1 prostanoid receptor EP1 receptor PGE receptor EP1 subtype PGE2 receptor EP1 subtype prostaglandin E receptor 1 (subtype EP1), 42kDa Prostanoid EP1 receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	405
Amino acid sequence	MSPCGLNLSLADEAATCATPRLPNTSVVLPTGDNGTSPALPIFSMTLGAVSNVLALALLAQVAGRMRRRRSAATFLLFVASLLAIDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTQPLIHAARVSVARARLALAVLAAMALAVALLPLVHVGRYELQYPGTWCFISLGPRGGWRQALLAGLFAGLGLAALLAALVCNTLSGLALLRARWRRRRSRRFRKTAGPDDRRRWGSRGPRLASASSASSITSATATLRSSRGGGSARRVHAHDVEMVGQLVGIMVVSCICWSPLLVLVVLAIGGWNSNSLQRPLFLAVRLASWNQILDPWVYILLRQAMLRQLLRLLPLRVSAKGGPTELGLTKSAWEASSLRSSRHSGFSHL
UniProt	P35375
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2181
IUPHAR	340
DrugBank	N/A

Ligand

Name	SCHEMBL213530
Molecular formula	C23H25ClN6O3S2
IUPAC name	N-[4-chloro-5-methyl-2-[[2-methyl-4-(2H-tetrazol-5-yl)phenyl]methoxy]phenyl]-4-methyl-N-propan-2-yl-1,3-thiazole-2-sulfonamide
Molecular weight	533.062
Hydrogen bond acceptor	9
Hydrogen bond donor	1
XlogP	5.2
Synonyms	US9181187, Compound J CHEMBL3967376 BDBM190572
Inchi Key	JBZJCVZNZYZYDH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H25ClN6O3S2/c1-13(2)30(35(31,32)23-25-16(5)12-34-23)20-9-15(4)19(24)10-21(20)33-11-18-7-6-17(8-14(18)3)22-26-28-29-27-22/h6-10,12-13H,11H2,1-5H3,(H,26,27,28,29)
PubChem CID	58891900
ChEMBL	CHEMBL3967376
IUPHAR	N/A
BindingDB	190572
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	4.9 nM	, None	BindingDB,ChEMBL

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