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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	2-Amino-N-ethyl-5-nitrobenzenesulfonanilide
Molecular formula	C14H15N3O4S
IUPAC name	2-amino-N-ethyl-5-nitro-N-phenylbenzenesulfonamide
Molecular weight	321.351
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	2.7
Synonyms	DivK1c_001267 MolPort-001-886-250 [(2-amino-5-nitrophenyl)sulfonyl]ethylphenylamine Cambridge id 5211953 CDS1_000227 HMS548K07 SMR000273874 2-Amino-N-ethyl-5-nitro-N-phenyl-benzenesulfonamide AC1Q6TSJ cid_67001 MCULE-2245518324 ST50336926 BDBM47496 EINECS 204-136-3 NCGC00245071-01 116-34-7 AB00075330-01 CBDivE_007463 KB-283203 SR-01000638030-1 2-amino-N-ethyl-5-nitro-N-phenylbenzenesulfonamide AKOS000560183 CTK8G6286 MLS000703410 ZINC3878596 2-azanyl-N-ethyl-5-nitro-N-phenyl-benzenesulfonamide Benzenesulfonamide, 2-amino-N-ethyl-5-nitro-N-phenyl- CCG-48494 HMS2659J20 SCHEMBL11141887 2-Amino-5-nitro-N-ethyl-N-phenylbenzenesulfonamide AC1L26MZ CHEMBL1562579 Maybridge1_002515 SR-01000638030-2 2-Amino-N-ethyl-5-nitro-N-phenylbenzenesulphonamide BAS 00328919 [ Show all ]
Inchi Key	AGSWRZMLPKYDNM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H15N3O4S/c1-2-16(11-6-4-3-5-7-11)22(20,21)14-10-12(17(18)19)8-9-13(14)15/h3-10H,2,15H2,1H3
PubChem CID	67001
ChEMBL	CHEMBL1562579
IUPHAR	N/A
BindingDB	47496
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	28183.8 nM	PubChem BioAssay data set	ChEMBL

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