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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 7
Species	Rattus norvegicus (Rat)
Gene	Htr7
Synonym	GPRFO 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 5-HTx 5-HT7 receptor 5-HT7 5-HT1Y 5-HT-X 5-HT-7 Serotonin receptor 7 [ Show all ]
Disease	N/A for non-human GPCRs
Length	448
Amino acid sequence	MMDVNSSGRPDLYGHLRSLILPEVGRGLQDLSPDGGAHPVVSSWMPHLLSGFLEVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVQPESVISLNGVVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERSEFVLQNSDHCGKKGHDT
UniProt	P32305
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3223
IUPHAR	12
DrugBank	N/A

Ligand

Name	SCHEMBL2277147
Molecular formula	C17H16N2O
IUPAC name	2-(azetidin-3-yloxy)-5-methyl-4-phenylbenzonitrile
Molecular weight	264.328
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	3.0
Synonyms	US8575364, 31 CHEMBL3640580 BDBM105022
Inchi Key	CVUWWMPCUXJJMR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H16N2O/c1-12-7-14(9-18)17(20-15-10-19-11-15)8-16(12)13-5-3-2-4-6-13/h2-8,15,19H,10-11H2,1H3
PubChem CID	46204734
ChEMBL	CHEMBL3640580
IUPHAR	N/A
BindingDB	105022
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	10000.0 nM	N/A	BindingDB
Ki	10000.0 nM	, None	BindingDB,ChEMBL

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