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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Prostaglandin E2 receptor EP1 subtype
Species	Mus musculus (Mouse)
Gene	Ptger1
Synonym	EP1 prostanoid receptor EP1 receptor PGE receptor EP1 subtype PGE2 receptor EP1 subtype prostaglandin E receptor 1 (subtype EP1), 42kDa Prostanoid EP1 receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	405
Amino acid sequence	MSPCGLNLSLADEAATCATPRLPNTSVVLPTGDNGTSPALPIFSMTLGAVSNVLALALLAQVAGRMRRRRSAATFLLFVASLLAIDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTQPLIHAARVSVARARLALAVLAAMALAVALLPLVHVGRYELQYPGTWCFISLGPRGGWRQALLAGLFAGLGLAALLAALVCNTLSGLALLRARWRRRRSRRFRKTAGPDDRRRWGSRGPRLASASSASSITSATATLRSSRGGGSARRVHAHDVEMVGQLVGIMVVSCICWSPLLVLVVLAIGGWNSNSLQRPLFLAVRLASWNQILDPWVYILLRQAMLRQLLRLLPLRVSAKGGPTELGLTKSAWEASSLRSSRHSGFSHL
UniProt	P35375
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2181
IUPHAR	340
DrugBank	N/A

Ligand

Name	SCHEMBL215462
Molecular formula	C26H30N2O5S
IUPAC name	4-[[4,5-dimethyl-2-[2-methylpropyl(pyridin-2-ylsulfonyl)amino]phenoxy]methyl]-3-methylbenzoic acid
Molecular weight	482.595
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	5.3
Synonyms	BDBM190570 US9181187, Compound H CHEMBL3956272
Inchi Key	AEANKAMGBZVZMQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H30N2O5S/c1-17(2)15-28(34(31,32)25-8-6-7-11-27-25)23-13-18(3)19(4)14-24(23)33-16-22-10-9-21(26(29)30)12-20(22)5/h6-14,17H,15-16H2,1-5H3,(H,29,30)
PubChem CID	23106384
ChEMBL	CHEMBL3956272
IUPHAR	N/A
BindingDB	190570
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	7.3 nM	, None	BindingDB,ChEMBL

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