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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Trace amine-associated receptor 7b
Species	Rattus norvegicus (Rat)
Gene	Taar7b
Synonym	TaR-12 TaR-7b Trace amine receptor 12 Trace amine receptor 7b
Disease	N/A for non-human GPCRs
Length	358
Amino acid sequence	MATDDDRFPWDQDSILSRDLLSASSMQLCYEKLNRSCVRSPYSPGPRLILYAVFGFGAVLAVCGNLLVMTSILHFRQLHSPANFLVASLACADFLVGLTVMPFSMVRSVEGCWYFGDIYCKFHSSFDGSFCYSSIFHLCFISADRYIAVSDPLIYPTRFTASVSGKCITFSWLLSIIYSFSLFYTGVNEAGLEDLVSALTCVGGCQIAVNQSWVFINFLLFLVPALVMMTVYSKIFLIAKQQAQNIEKMGKQTARASESYKDRVAKRERKAAKTLGIAVAAFLLSWLPYFIDSIIDAFLGFVTPTYVYEILVWIGYYNSAMNPLIYAFFYPWFRKAIKLIVTGKILRENSSATNLFPE
UniProt	Q923X8
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2176813
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL3641727
Molecular formula	C18H18N4O
IUPAC name	N-[4-[(2R)-morpholin-2-yl]phenyl]quinazolin-2-amine
Molecular weight	306.369
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	2.4
Synonyms	BDBM129535 SCHEMBL12610032 US8802673, 177
Inchi Key	CVJFJKFBKXBOGY-KRWDZBQOSA-N
Inchi ID	InChI=1S/C18H18N4O/c1-2-4-16-14(3-1)11-20-18(22-16)21-15-7-5-13(6-8-15)17-12-19-9-10-23-17/h1-8,11,17,19H,9-10,12H2,(H,20,21,22)/t17-/m0/s1
PubChem CID	68325740
ChEMBL	CHEMBL3641727
IUPHAR	N/A
BindingDB	129535
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	29.9 nM	, None	BindingDB,ChEMBL

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