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Name | Vasopressin V2 receptor |
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Species | Rattus norvegicus (Rat) |
Gene | Avpr2 |
Synonym | AVPR V2 Antidiuretic hormone receptor ADHR Renal-type arginine vasopressin receptor V2 receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 371 |
Amino acid sequence | MLLVSTVSAVPGLFSPPSSPSNSSQEELLDDRDPLLVRAELALLSTIFVAVALSNGLVLGALIRRGRRGRWAPMHVFISHLCLADLAVALFQVLPQLAWDATDRFHGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQRDVGNGSGVFDCWARFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHASLVPGPSERAGRRRRGRRTGSPSEGAHVSAAMAKTVRMTLVIVIVYVLCWAPFFLVQLWAAWDPEAPLERPPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCAQRHTTHSLGPQDESCATASSSLMKDTPS |
UniProt | Q00788 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3766 |
IUPHAR | 368 |
DrugBank | N/A |
Name | CHEMBL339155 |
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Molecular formula | C31H47N3O3S |
IUPAC name | N-[(1S,2S,4R)-7,7-dimethyl-1-(spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylsulfonylmethyl)-2-bicyclo[2.2.1]heptanyl]-3-piperidin-3-ylpropanamide |
Molecular weight | 541.795 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 2 |
XlogP | 4.7 |
Synonyms | BDBM50043131 1N-[7,7-dimethyl-1-spiro[2,3-dihydro-1H-indene-1,4''-(hexahydropyridine)]-1-ylsulfonylmethyl-(1S,2S,4R)-bicyclo[2.2.1]hept-2-yl]-3-hexahydro-3-pyridinylpropanamide |
Inchi Key | CVHZNGFFODOVCS-SQELAJNSSA-N |
Inchi ID | InChI=1S/C31H47N3O3S/c1-29(2)25-12-14-31(29,27(20-25)33-28(35)10-9-23-6-5-17-32-21-23)22-38(36,37)34-18-15-30(16-19-34)13-11-24-7-3-4-8-26(24)30/h3-4,7-8,23,25,27,32H,5-6,9-22H2,1-2H3,(H,33,35)/t23?,25-,27+,31-/m1/s1 |
PubChem CID | 9984805 |
ChEMBL | CHEMBL339155 |
IUPHAR | N/A |
BindingDB | 50043131 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 5200.0 nM | PMID8258821 | BindingDB,ChEMBL |
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