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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 1A
Species	Rattus norvegicus (Rat)
Gene	Htr1a
Synonym	5-HT1A receptor 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 5-HT1A ADRB2RL1 ADRBRL1 5-HT-1A Gpcr18 Serotonin receptor 1A [ Show all ]
Disease	N/A for non-human GPCRs
Length	422
Amino acid sequence	MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
UniProt	P19327
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL273
IUPHAR	1
DrugBank	N/A

Ligand

Name	CHEMBL133375
Molecular formula	C28H40N2O4
IUPAC name	8-[4-(1'-propylspiro[2,4-dihydrochromene-3,2'-pyrrolidine]-5-yl)oxybutyl]-8-azaspiro[4.5]decane-7,9-dione
Molecular weight	468.638
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	4.9
Synonyms	8-[4-[[1'-Propylspiro[2H-1-benzopyran-3(4H),2'-pyrrolidin]-5-yl]oxy]butyl]-8-azaspiro[4.5]decane-7,9-dione 8-{4-[1''-propylspiro[3,4-dihydro-2H-chromene-3,2''-(tetrahydro-1''H-pyrrole)]-5-yloxy]butyl}-8-azaspiro[4.5]decane-7,9-dione BDBM50054155 SCHEMBL8556860
Inchi Key	CVBMSXGNWVNTDT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C28H40N2O4/c1-2-14-29-15-8-13-28(29)18-22-23(9-7-10-24(22)34-21-28)33-17-6-5-16-30-25(31)19-27(20-26(30)32)11-3-4-12-27/h7,9-10H,2-6,8,11-21H2,1H3
PubChem CID	10838030
ChEMBL	CHEMBL133375
IUPHAR	N/A
BindingDB	50054155
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	101.0 nM	PMID8863806	BindingDB,ChEMBL

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