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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Sphingosine 1-phosphate receptor 2
Species	Rattus norvegicus (Rat)
Gene	S1pr2
Synonym	S1P2 receptor S1P2 S1P receptor Edg-5 S1P receptor 2 GPCR18 Gpcr13 G-protein coupled receptor H218 G protein-coupled receptor 13 Endothelial differentiation G-protein coupled receptor 5 endothelial differentiation G protein-coupled receptor 5 edg5 AGR16 Sphingosine 1-phosphate receptor Edg-5 [ Show all ]
Disease	N/A for non-human GPCRs
Length	352
Amino acid sequence	MGGLYSEYLNPEKVQEHYNYTKETLDMQETPSRKVASAFIIILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGPVTLSLTPLQWFAREGSAFITLSASVFSLLAIAIERQVAIAKVKLYGSDKSCRMLMLIGASWLISLILGGLPILGWNCLDHLEACSTVLPLYAKHYVLCVVTIFSVILLAIVALYVRIYFVVRSSHADVAGPQTLALLKTVTIVLGVFIICWLPAFSILLLDSTCPVRACPVLYKAHYFFAFATLNSLLNPVIYTWRSRDLRREVLRPLLCWRQGKGATGRRGGNPGHRLLPLRSSSSLERGLHMPTSPTFLEGNTVV
UniProt	P47752
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3616360
IUPHAR	276
DrugBank	N/A

Ligand

Name	CHEMBL3401383
Molecular formula	C31H36FN3O5
IUPAC name	N-[3-(4-carbamoylphenoxy)-5-(4-fluorophenoxy)phenyl]-4-(2-ethylbutyl)-4-hydroxypiperidine-1-carboxamide
Molecular weight	549.643
Hydrogen bond acceptor	6
Hydrogen bond donor	3
XlogP	5.6
Synonyms	BDBM50065611 SCHEMBL14839322
Inchi Key	XWGOCGLJLLJAOE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C31H36FN3O5/c1-3-21(4-2)20-31(38)13-15-35(16-14-31)30(37)34-24-17-27(39-25-9-5-22(6-10-25)29(33)36)19-28(18-24)40-26-11-7-23(32)8-12-26/h5-12,17-19,21,38H,3-4,13-16,20H2,1-2H3,(H2,33,36)(H,34,37)
PubChem CID	89484779
ChEMBL	CHEMBL3401383
IUPHAR	N/A
BindingDB	50065611
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	4.8 nM	PMID26384288	BindingDB,ChEMBL

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