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GPCR

Name	Alpha-2B adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA2B
Synonym	alpha2-C2 alpha2B alpha2B-adrenoceptor Alpha-2BAR alpha-2B adrenoreceptor Alpha-2B adrenoceptor alpha-2B adrenergic receptor Alpha-2 adrenergic receptor subtype C2 adrenergic receptor Adrenergic alpha2B- receptor class III ADRA2RL1 ADRA2L1 Adra-2b [ Show all ]
Disease	Neuropathic pain Alcohol use disorders
Length	450
Amino acid sequence	MDHQDPYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGSFFAPCLIMILVYLRIYLIAKRSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALASVASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEEEEEEEEEEEECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRILCRPWTQTAW
UniProt	P18089
Protein Data Bank	N/A
GPCR-HGmod model	P18089
3D structure model	This predicted structure model is from GPCR-EXP P18089.
BioLiP	N/A
Therapeutic Target Database	T41580
ChEMBL	CHEMBL1942
IUPHAR	26
DrugBank	BE0000572

Ligand

Name	143069-08-3
Molecular formula	C25H26N4
IUPAC name	N-[4-(4-ethylpiperazin-1-yl)phenyl]acridin-9-amine
Molecular weight	382.511
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	5.4
Synonyms	CBDivE_005028 N-(4-(4-Ethyl-1-piperazinyl)phenyl)-9-acridinamine 9-Acridinamine,N-[4-(4-ethyl-1-piperazinyl)phenyl]- CTK4C3465 TCMDC-124255 AKOS030561802 GNF-PF-3878 N-(4-(4-ethylpiperazin-1-yl)phenyl)acridin-9-amine AC1MILKO D07ICV BDBM50196122 LS-14146 9-Acridinamine, N-(4-(4-ethyl-1-piperazinyl)phenyl)- CHEMBL217366 N-[4-(4-ethylpiperazin-1-yl)phenyl]acridin-9-amine ACMC-20n23a DTXSID10162300 [ Show all ]
Inchi Key	CUVBGWMAORETGV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H26N4/c1-2-28-15-17-29(18-16-28)20-13-11-19(12-14-20)26-25-21-7-3-5-9-23(21)27-24-10-6-4-8-22(24)25/h3-14H,2,15-18H2,1H3,(H,26,27)
PubChem CID	3072540
ChEMBL	CHEMBL217366
IUPHAR	N/A
BindingDB	50196122
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1200.0 nM	PMID17034141	BindingDB,ChEMBL

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