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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
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GPCR

Name	Cannabinoid receptor 2
Species	Homo sapiens (Human)
Gene	CNR2
Synonym	Peripheral cannabinoid receptor rCB2 hCB2 cannabinoid receptor 2 (macrophage) cannabinoid receptor 2 (spleen) CB-2 CB2 CB2 receptor CB2-R CX5 [ Show all ]
Disease	Immune disorder Inflammatory bowel disease Inflammatory disease Neuropathic pain Osteoporosis Pain Atopic dermatitis Rheumatoid arthritis [ Show all ]
Length	360
Amino acid sequence	MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
UniProt	P34972
Protein Data Bank	5zty
GPCR-HGmod model	P34972
3D structure model	This structure is from PDB ID 5zty.
BioLiP	BL0438927
Therapeutic Target Database	T37693
ChEMBL	CHEMBL253
IUPHAR	57
DrugBank	BE0000095

Ligand

Name	CHEMBL256781
Molecular formula	C24H30N2O4S
IUPAC name	2-[(4-ethoxyphenyl)methyl]-5-ethylsulfonyl-1-(oxan-4-ylmethyl)benzimidazole
Molecular weight	442.574
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	3.9
Synonyms	BDBM50376566
Inchi Key	AGPVLEDUINGMDZ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H30N2O4S/c1-3-30-20-7-5-18(6-8-20)15-24-25-22-16-21(31(27,28)4-2)9-10-23(22)26(24)17-19-11-13-29-14-12-19/h5-10,16,19H,3-4,11-15,17H2,1-2H3
PubChem CID	44449380
ChEMBL	CHEMBL256781
IUPHAR	N/A
BindingDB	50376566
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	4.0 nM	PMID18394887	BindingDB,ChEMBL
Efficacy	44.0 %	PMID18394887	ChEMBL

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