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GPCR

Name	Parathyroid hormone/parathyroid hormone-related peptide receptor
Species	Homo sapiens (Human)
Gene	PTH1R
Synonym	PTH1 receptor PTHR PTH/PTHrP type I receptor PTH/PTHr receptor PPR Parathyroid hormone 1 receptor PTHR1 [ Show all ]
Disease	N/A
Length	593
Amino acid sequence	MGTARIAPGLALLLCCPVLSSAYALVDADDVMTKEEQIFLLHRAQAQCEKRLKEVLQRPASIMESDKGWTSASTSGKPRKDKASGKLYPESEEDKEAPTGSRYRGRPCLPEWDHILCWPLGAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVKFLTNETREREVFDRLGMIYTVGYSVSLASLTVAVLILAYFRRLHCTRNYIHMHLFLSFMLRAVSIFVKDAVLYSGATLDEAERLTEEELRAIAQAPPPPATAAAGYAGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTVFGWGLPAVFVAVWVSVRATLANTGCWDLSSGNKKWIIQVPILASIVLNFILFINIVRVLATKLRETNAGRCDTRQQYRKLLKSTLVLMPLFGVHYIVFMATPYTEVSGTLWQVQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIKKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRVGLGLPLSPRLLPTATTNGHPQLPGHAKPGTPALETLETTPPAMAAPKDDGFLNGSCSGLDEEASGPERPPALLQEEWETVM
UniProt	Q03431
Protein Data Bank	6fj3, 3h3g, 3c4m
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 6fj3.
BioLiP	BL0161387, BL0433539,BL0433540, BL0161388, BL0143680,BL0143682, BL0143681,BL0143683
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1793
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CROMOLYN SODIUM
Molecular formula	C23H14Na2O11
IUPAC name	disodium;5-[3-(2-carboxylato-4-oxochromen-5-yl)oxy-2-hydroxypropoxy]-4-oxochromene-2-carboxylate
Molecular weight	512.334
Hydrogen bond acceptor	11
Hydrogen bond donor	1
XlogP	None
Synonyms	SPECTRUM1500210 Sodium Chromoglycate Disodium 5,5'-((2-hydroxytrimethylene)dioxy)bis(4-oxo-4H-1-benzopyran-2-carboxylate) disodium cromoglycate(2-) 16110-51-3 (Cromolyn) Epitope ID:122681 5,5'-((2-Hydroxytrimethylene)dioxy)bis(4-oxo-4H-1-benzopyran-2-carboxylic acid) disodium salt Gastrocrom (TN) AB0013247 HMS2091I06 AKOS016339565 Intal CAS-15826-37-6 Lomuda Cromo asma aerosol Nalcrom NCGC00017083-03 CTK8F0841 Opticrom Sodium cromoglicate [JAN] Tox21_110863_1 RTR-006665 disodium 5-[3-(2-carboxylato-4-oxo-4H-5-chromenyloxy)-2-hydroxypropoxy]-4-oxo-4H-2-chromenecarboxylate DSSTox_CID_24554 16636-EP2316459A1 FPL.670 5-[3-(2-carboxy-4-oxochromen-5-yloxy)-2-hydroxypropoxy]-4-oxochromene-2-carbox ylic acid, sodium salt, sodium salt Gynazole AC1L1DCY HMS502K19 B3300 J10281 CHEBI:128458 Lomusol Cromoglycate disodium Natrii cromoglicas Cromolyn sodium [USAN:USP] NCGC00094633-01 Dinatrium cromoglicicum Sodium Cromoylycate Vicrom SCHEMBL7500 disodium 5-{3-[(2-carboxylato-4-oxo-4H-chromen-5-yl)oxy]-2-hydroxypropoxy}-4-oxo-4H-chromene-2-carboxylate 105878-73-7 DTXSID7044554 4H-1-Benzopyran-2-carboxylic acid, 5,5'-((2-hydroxytrimethylene)dioxy)bis(4-oxo-, disodium salt FT-0602030 Aarane HMS1920A18 AKOS015895760 I14-45144 C23H14Na2O11 KS-5299 Chromolyn sodium MFCD00057744 Cromolyn (sodium) NCGC00017083-01 Cromoptic Nebulasma dipotassium cromoglycate(2-) ST50999688 sodium cromoglicate disodium 5,5'-[(2-hydroxypropane-1,3-diyl)bis(oxy)]bis(4-oxo-4H-chromene-2-carboxylate) disodium;5-[3-(2-carboxylato-4-oxochromen-5-yl)oxy-2-hydroxypropoxy]-4-oxochromene-2-carboxylate 16636-EP2281563A1 FPL 670 5,5'-(2-Hydroxytrimethylenedioxy)bis(4-oxochromene-2-carboxylic acid) Gastrofrenal AB2000369 HMS2097D05 AN-8075 Intal nebulizer CCG-40261 Lomudal Cromoglicinsaeure, dinatriumsalz Nasalcrom Cromolyn sodium (USP) NCGC00021142-02 D00526 Prestwick_996 Sodium cromoglycate Tox21_302003 Rynacrom disodium 5-[3-(2-carboxylato-4-oxo-chromen-5-yl)oxy-2-hydroxy-propoxy]-4-oxo-chromene-2-carboxylate 1,3-Bis(2-carboxychromon-5-yloxy)-2-hydroxypropane DSSTox_GSID_44554 4H-1-Benzopyran-2-carboxylic acid, 5,5'-((2-hydroxy-1,3-propanediyl)bis(oxy))bis(4-oxo-, disodium salt Frenasma 87016-01-1 H769 ACMC-20eni6 HY-B0320A BCP12933 K-4967 LS-39176 Cromoglycate,Cromoglycic acid Natrium cromoglicat Cromolyn sodium [USAN] NCGC00094633-02 Dinatrium salz von 1,3-bis-(2-carboxychromon-5-yloxy)-2-hydroxypropan Sodium salt of 5-[3-(2-carboxy-4-oxo-4H-5-chromenyloxy)-2-hydroxypropoxy]-4-oxo-4H-2-chromenecarboxylic acid sodium 5,5'-(2-hydroxypropane-1,3-diyl)bis(oxy)bis(4-oxo-4H-chromene-2-carboxylate) Disodium 5,5'-((2-hydroxytrimethylene)bis(oxy))bis(4-oxo-4H-1-benzopyran-2-carboxylate) Disodium cromoglycate 15826-37-6 EINECS 239-926-7 4H-1-Benzopyran-2-carboxylic acid, 5,5'-((2-hydroxytrimethylene)dioxy)bis(4-oxo-,disodium salt Gastrocrom Aararre HMS2089N09 AKOS015913923 Inostral (Anti-asthmatic) C23H14O11.2Na KSC950Q4D Crolom MolPort-002-509-361 Cromolyn disodium salt NCGC00017083-02 CS-2361 NSC 109500 Sodium cromoglicate (JP17) Tox21_110863 Disodium 5,5'-[(2-hydroxytrimethylene)dioxy]bis[4-oxo-4H-1-benzopyran-2-carboxylate] DSCG 16636-EP2314298A1 FPL-670 5,5'-[(2-Hydroxy-1,3-propanediyl)bis(oxy)]bis(4-oxo-4H-1-benzopyran-2-carboxylic Acid) Disodium Salt GP8420 AC-18734 HMS3714D05 API0002134 J-009487 CCRIS 3194 Lomudas Cromoglycate Nasmil Cromolyn sodium salt NCGC00022858-08 D01IGI Q2WXR1I0PK Sodium cromolyn UNII-Q2WXR1I0PK s1911 disodium 5-[3-(2-carboxylato-4-oxochromen-5-yl)oxy-2-hydroxypropoxy]-4-oxochromene-2-carboxylate 1,3-Di(2-carboxy-4-oxochromen-5-yloxy)propan-2-ol DSSTox_RID_80311 4H-1-Benzopyran-2-carboxylic acid, 5,5'-((2-hydroxy-1,3-propanediyl)bis(oxy))bis(4-oxo-, disodium salt) FT-0082168 93356-84-4 HMS1570D05 AK163517 I06-1500 Bicromat Spray KS-00000FYJ CHEMBL74 MCULE-8432777058 Cromoglycic acid Natrium cromoglicat [German] Cromolynsodium NCGC00255950-01 Dinatrium salz von 1,3-bis-(2-carboxychromon-5-yloxy)-2-hydroxypropan [German] [ Show all ]
Inchi Key	VLARUOGDXDTHEH-UHFFFAOYSA-L
Inchi ID	InChI=1S/C23H16O11.2Na/c24-11(9-31-14-3-1-5-16-20(14)12(25)7-18(33-16)22(27)28)10-32-15-4-2-6-17-21(15)13(26)8-19(34-17)23(29)30;;/h1-8,11,24H,9-10H2,(H,27,28)(H,29,30);;/q;2*+1/p-2
PubChem CID	27503
ChEMBL	CHEMBL74
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
Potency	22387.2 nM	PubChem BioAssay data set	ChEMBL

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