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GPCR

Name	Parathyroid hormone/parathyroid hormone-related peptide receptor
Species	Homo sapiens (Human)
Gene	PTH1R
Synonym	PTH1 receptor PTHR PTH/PTHrP type I receptor PTH/PTHr receptor PPR Parathyroid hormone 1 receptor PTHR1 [ Show all ]
Disease	N/A
Length	593
Amino acid sequence	MGTARIAPGLALLLCCPVLSSAYALVDADDVMTKEEQIFLLHRAQAQCEKRLKEVLQRPASIMESDKGWTSASTSGKPRKDKASGKLYPESEEDKEAPTGSRYRGRPCLPEWDHILCWPLGAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVKFLTNETREREVFDRLGMIYTVGYSVSLASLTVAVLILAYFRRLHCTRNYIHMHLFLSFMLRAVSIFVKDAVLYSGATLDEAERLTEEELRAIAQAPPPPATAAAGYAGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTVFGWGLPAVFVAVWVSVRATLANTGCWDLSSGNKKWIIQVPILASIVLNFILFINIVRVLATKLRETNAGRCDTRQQYRKLLKSTLVLMPLFGVHYIVFMATPYTEVSGTLWQVQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIKKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRVGLGLPLSPRLLPTATTNGHPQLPGHAKPGTPALETLETTPPAMAAPKDDGFLNGSCSGLDEEASGPERPPALLQEEWETVM
UniProt	Q03431
Protein Data Bank	6fj3, 3h3g, 3c4m
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 6fj3.
BioLiP	BL0161387, BL0433539,BL0433540, BL0161388, BL0143680,BL0143682, BL0143681,BL0143683
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1793
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	naphthalene
Molecular formula	C10H8
IUPAC name	naphthalene
Molecular weight	128.174
Hydrogen bond acceptor	0
Hydrogen bond donor	0
XlogP	3.3
Synonyms	Naphthalene, United States Pharmacopeia (USP) Reference Standard CHEBI:16482 Naphthene DTXSID8020913 NCGC00254058-01 I14-6944 RCRA waste number U165 MFCD00001742 Tox21_111023 mothballr UNII-0TNN3Q0D4D component UFWIBTONFRDIAS-UHFFFAOYSA-N naphtalene Naphthalene 10 microg/mL in Cyclohexane Naphthalene, 99+%, scintillation grade ACMC-209r8h Naphthalene, for synthesis, 98.5% BDBM50159249 C00829 Naphthalin Dezodorator NCGC00090793-01 EPA Pesticide Chemical Code 055801 NPY KS-00000VGR SMR000677944 MLS001055498 UFWIBTONFRDIAS-UHFFFAOYSA-N N0885 WLN: L66J Naphtalinum Naphthalene solution, certified reference material, 200 mug/mL in methanol 68412-25-9 Naphthalene, crude AKOS000119977 Naphthalene, molten [UN2304] [Flammable solid] Naphthalene, SAJ first grade, >=98.0% Caswell No. 587 Naphthalinum DSSTox_GSID_20913 NCGC00090793-04 HMS3039N15 NSC37565 MCULE-8231589350 STL282720 moth flaker UN1334 naftaleno Naphthalene (molten) Naphthalene, 98% AB1003134 Naphthalene, crude or refined [UN1334] [Flammable solid] antimitr Naphthalene,(S) Naphthyl Group EC 202-049-5 NCGC00259553-01 InChI=1/C10H8/c1-2-6-10-8-4-3-7-9(10)5-1/h1-8 RTR-003288 Mighty 150 Tox21_202004 Mothballs UNII-2166IN72UN Naphtalene [ISO:French] Naphthalene 100 microg/mL in Acetonitrile 2166IN72UN Naphthalene, analytical standard AI3-00278 Naphthalene, molten Bicyclo[4.4.0]deca-1,3,5,7,9-pentene Camphor tar Naphthaline Di(C5-C6)alkylnaphthalene NCGC00090793-02 F0001-2217 NSC 37565 L001166 SR-01000854997 MolPort-001-738-535 UN 1334 Naftalen ZB015456 naphthalen Naphthalene solution, certified reference material, 5000 mug/mL in methanol 72931-45-4 Naphthalene, crude or refined Albocarbon Naphthalene, Pharmaceutical Secondary Standard; Certified Reference Material Naphthalene, suitable for scintillation, >=99% CCRIS 1838 naphthalir DSSTox_RID_75860 NCGC00090793-05 HSDB 184 RCRA waste no. U165 Melting point standard 79-81C, analytical standard Tar camphor Moth flakes UN2304 naftalina Naphthalene 10 microg/mL in Acetonitrile Naphthalene, 99% AC1L1ACK Naphthalene, di-C5-6-alkyl derivs. ANW-39567 BIDD:ER0665 NAPHTHALENE- D8 CHEMBL16293 napthalene EINECS 202-049-5 NCI-C52904 KB-57607 S652 Mighty RD1 Tox21_300008 N0004 White tar naphtaline Naphthalene solution, 100 ng/muL in cyclohexane, analytical standard Naphthalene, certified reference material, TraceCERT(R) AJ-24528 Naphthalene, molten [UN2304] [Flammable solid] CAS-91-20-3 naphthalinr DSSTox_CID_913 NCGC00090793-03 FT-0651884 NSC-37565 LS-1917 SR-01000854997-2 Moth balls UN 2304 Naftalen [Polish] ZINC967522 Naphthalene [BSI:ISO] 91-20-3 Naphthalene, crude or refined [UN1334] [Flammable solid] AN-42549 Naphthalene, pure [ Show all ]
Inchi Key	UFWIBTONFRDIAS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H8/c1-2-6-10-8-4-3-7-9(10)5-1/h1-8H
PubChem CID	931
ChEMBL	CHEMBL16293
IUPHAR	N/A
BindingDB	50159249
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	4466.8 nM	PubChem BioAssay data set	ChEMBL

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