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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Prostaglandin E2 receptor EP1 subtype
Species	Rattus norvegicus (Rat)
Gene	Ptger1
Synonym	EP1 prostanoid receptor EP1 receptor PGE receptor EP1 subtype PGE2 receptor EP1 subtype prostaglandin E receptor 1 (subtype EP1), 42kDa prostanoid EP1 receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	405
Amino acid sequence	MSPYGLNLSLVDEATTCVTPRVPNTSVVLPTGGNGTSPALPIFSMTLGAVSNVLALALLAQVAGRLRRRRSTATFLLFVASLLAIDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTQPLIHAARVSVARARLALALLAAMALAVALLPLVHVGHYELQYPGTWCFISLGPPGGWRQALLAGLFAGLGLAALLAALVCNTLSGLALLRARWRRRRSRRFRENAGPDDRRRWGSRGLRLASASSASSITSTTAALRSSRGGGSARRVHAHDVEMVGQLVGIMVVSCICWSPLLVLVVLAIGGWNSNSLQRPLFLAVRLASWNQILDPWVYILLRQAMLRQLLRLLPLRVSAKGGPTELSLTKSAWEASSLRSSRHSGFSHL
UniProt	P70597
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5068
IUPHAR	340
DrugBank	N/A

Ligand

Name	SCHEMBL6118481
Molecular formula	C21H18N2O3S
IUPAC name	6-[(5-methoxy-6-methyl-2-thiophen-3-ylindol-1-yl)methyl]pyridine-2-carboxylic acid
Molecular weight	378.446
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	4.1
Synonyms	US8680120, 25-39 CHEMBL3665574 BDBM119480
Inchi Key	CTPVPIPUPQBRGA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H18N2O3S/c1-13-8-18-15(10-20(13)26-2)9-19(14-6-7-27-12-14)23(18)11-16-4-3-5-17(22-16)21(24)25/h3-10,12H,11H2,1-2H3,(H,24,25)
PubChem CID	50907868
ChEMBL	CHEMBL3665574
IUPHAR	N/A
BindingDB	119480
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	37.0 nM	, None	BindingDB,ChEMBL

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