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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Cysteinyl leukotriene receptor 2
Species	Homo sapiens (Human)
Gene	CYSLTR2
Synonym	CysLTR2 CysLT2 receptor LTC4 HPN321 hGPCR21 HG57 G-protein coupled receptor HG57 CYSLT2R G-protein coupled receptor GPCR21 [ Show all ]
Disease	Unspecified Asthma
Length	346
Amino acid sequence	MERKFMSLQPSISVSEMEPNGTFSNNNSRNCTIENFKREFFPIVYLIIFFWGVLGNGLSIYVFLQPYKKSTSVNVFMLNLAISDLLFISTLPFRADYYLRGSNWIFGDLACRIMSYSLYVNMYSSIYFLTVLSVVRFLAMVHPFRLLHVTSIRSAWILCGIIWILIMASSIMLLDSGSEQNGSVTSCLELNLYKIAKLQTMNYIALVVGCLLPFFTLSICYLLIIRVLLKVEVPESGLRVSHRKALTTIIITLIIFFLCFLPYHTLRTVHLTTWKVGLCKDRLHKALVITLALAAANACFNPLLYYFAGENFKDRLKSALRKGHPQKAKTKCVFPVSVWLRKETRV
UniProt	Q9NS75
Protein Data Bank	N/A
GPCR-HGmod model	Q9NS75
3D structure model	This predicted structure model is from GPCR-EXP Q9NS75.
BioLiP	N/A
Therapeutic Target Database	T74238
ChEMBL	CHEMBL4330
IUPHAR	270
DrugBank	BE0000099

Ligand

Name	CHEMBL3597627
Molecular formula	C37H40ClNO5
IUPAC name	5-[3-(3-carboxypropyl)-7-[2-[4-[4-(3-chloro-2-methylphenyl)butoxy]phenyl]ethynyl]-2-methylindol-1-yl]pentanoic acid
Molecular weight	614.179
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	8.3
Synonyms	BDBM50104914
Inchi Key	RTFGIFVDEZMXFW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C37H40ClNO5/c1-26-29(11-8-15-34(26)38)10-4-6-25-44-31-22-19-28(20-23-31)18-21-30-12-7-14-33-32(13-9-17-36(42)43)27(2)39(37(30)33)24-5-3-16-35(40)41/h7-8,11-12,14-15,19-20,22-23H,3-6,9-10,13,16-17,24-25H2,1-2H3,(H,40,41)(H,42,43)
PubChem CID	122183761
ChEMBL	CHEMBL3597627
IUPHAR	N/A
BindingDB	50104914
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	30.0 nM	PMID26200813	BindingDB,ChEMBL

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