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Name | Type-1B angiotensin II receptor |
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Species | Rattus norvegicus (Rat) |
Gene | Agtr1b |
Synonym | Angiotensin II type-1B receptor AT1B AT3 |
Disease | N/A for non-human GPCRs |
Length | 359 |
Amino acid sequence | MTLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIYRNVYFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFVFPFLIILTSYTLIWKALKKAYKIQKNTPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIRDCEIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPTAKSHAGLSTKMSTLSYRPSDNMSSSAKKSASFFEVE |
UniProt | P29089 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL263 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL313222 |
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Molecular formula | C29H31N7O |
IUPAC name | 5-butyl-2-(3-phenylpropyl)-4-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-1,2,4-triazol-3-one |
Molecular weight | 493.615 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 1 |
XlogP | 5.6 |
Synonyms | L006303 5-Butyl-2-(3-phenyl-propyl)-4-[2''-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-2,4-dihydro-[1,2,4]triazol-3-one 4-[[2'-(1H-Tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl]-2-(3-phenylpropyl)-5-butyl-2H-1,2,4-triazol-3(4H)-one SCHEMBL7399866 5-Butyl-2-(3-phenyl-propyl)-4-[2''-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-2,4-dihydro-[1,2,4]triazol-3-one [ Show all ] |
Inchi Key | CSQXFYGNSGJKRX-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C29H31N7O/c1-2-3-15-27-32-36(20-9-12-22-10-5-4-6-11-22)29(37)35(27)21-23-16-18-24(19-17-23)25-13-7-8-14-26(25)28-30-33-34-31-28/h4-8,10-11,13-14,16-19H,2-3,9,12,15,20-21H2,1H3,(H,30,31,33,34) |
PubChem CID | 14956804 |
ChEMBL | CHEMBL313222 |
IUPHAR | N/A |
BindingDB | 50044364 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 18.0 nM | PMID8340920 | BindingDB,ChEMBL |
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