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GLASS

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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	1-(4-Chloro-3-nitro-benzenesulfonyl)-azepane
Molecular formula	C12H15ClN2O4S
IUPAC name	1-(4-chloro-3-nitrophenyl)sulfonylazepane
Molecular weight	318.772
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	2.7
Synonyms	A2197/0092457 cid_3114950 NE41288 AKOS000115072 EU-0071179 SR-01000751992-2 1-(4-chloro-3-nitrophenyl)sulfonylazepane MLS000713515 ZINC3885195 4-(azaperhydroepinylsulfonyl)-1-chloro-2-nitrobenzene AC1MJMS0 CTK5I2568 SMR000272996 1-(4-chloro-3-nitro-phenyl)sulfonylazepane BAS 00668099 HMS2655J24 ST4053214 1-[(4-chloro-3-nitrophenyl)sulfonyl]azepane CHEMBL1458112 MolPort-000-679-667 1-(4-chloranyl-3-nitro-phenyl)sulfonylazepane AC1Q1WXO EN300-01531 SR-01000751992 1-(4-chloro-3-nitrobenzenesulfonyl)azepane BDBM62112 MCULE-2218611837 STK721843 312594-40-4 [ Show all ]
Inchi Key	CRHJSGALSIKJLW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C12H15ClN2O4S/c13-11-6-5-10(9-12(11)15(16)17)20(18,19)14-7-3-1-2-4-8-14/h5-6,9H,1-4,7-8H2
PubChem CID	3114950
ChEMBL	CHEMBL1458112
IUPHAR	N/A
BindingDB	62112
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	31622.8 nM	PubChem BioAssay data set	ChEMBL

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