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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Hydroxycarboxylic acid receptor 2
Species	Homo sapiens (Human)
Gene	HCAR2
Synonym	G protein-coupled receptor 109A PUMAG Nicotinic acid receptor Nic1 Niacr1 Niacin receptor 1 G-protein coupled receptor 109A G-protein coupled receptor HM74A HCA2 receptor [ Show all ]
Disease	Type 2 diabetes Hyperlipidaemia Major depressive disorder Cardiovascular disorder Atherosclerosis Arteriosclerosis Acute ischemic stroke [ Show all ]
Length	363
Amino acid sequence	MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
UniProt	Q8TDS4
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDS4
3D structure model	This predicted structure model is from GPCR-EXP Q8TDS4.
BioLiP	N/A
Therapeutic Target Database	T00864
ChEMBL	CHEMBL3785
IUPHAR	312
DrugBank	BE0000635

Ligand

Name	14779-25-0
Molecular formula	C8H8O3
IUPAC name	(E)-3-(5-methylfuran-2-yl)prop-2-enoic acid
Molecular weight	152.149
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	1.4
Synonyms	BBL023058 IDI1_007557 SCHEMBL2720407 (2E)-3-(5-methyl-2-furyl)acrylic acid 3-(5-methyl-2-furyl)acrylic acid AC1Q2MN6 AKOS000263783 CHEMBL1651774 MolPort-000-874-605 TR-005911 (E)-3-(5-Methyl-2-furyl)acrylic acid 3-(5-methylfuran-2-yl)prop-2-enoic acid ARONIS002889 HTS000648 SBB005723 (E)-3-(5-Methylfuran-2-yl)prop-2-enoic acid AB0154766 BS-3838 J-510768 ST45039690 (2E)-3-(5-methylfuran-2-yl)prop-2-enoic acid 3-(5-methyl-furan-2-yl)-acrylic acid AC1Q5RB4 AKOS023502344 EN300-05241 MolPort-009-655-799 Y-8997 (E)-3-(5-Methyl-furan-2-yl)-acrylic acid 5-Methyl-2-furanacrylic acid BB 0254601 I04-4576 SCHEMBL2720405 (2E)-3-(5-methyl(2-furyl))prop-2-enoic acid AC1LG8IK KB-27273 STK035006 (E)-3-(5-methyl-2-furyl)-2-propenoic acid 3-(5-methylfuran-2-yl)acrylic acid AH-034/11364010 ALBB-007466 HMS1408B20 Prop-2-enoic acid, 3-(5-methylfuran-2-yl)-, (E)- ZINC243961 (E)-3-(5-methylfuran-2-yl)acrylic acid 54160-40-6 [ Show all ]
Inchi Key	CQCKLDAUFPKXPU-SNAWJCMRSA-N
Inchi ID	InChI=1S/C8H8O3/c1-6-2-3-7(11-6)4-5-8(9)10/h2-5H,1H3,(H,9,10)/b5-4+
PubChem CID	766922
ChEMBL	CHEMBL1651774
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	7.0 %	PMID21167710	ChEMBL

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