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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Parathyroid hormone/parathyroid hormone-related peptide receptor
Species	Homo sapiens (Human)
Gene	PTH1R
Synonym	PTH1 receptor PTHR PTH/PTHrP type I receptor PTH/PTHr receptor PPR Parathyroid hormone 1 receptor PTHR1 [ Show all ]
Disease	N/A
Length	593
Amino acid sequence	MGTARIAPGLALLLCCPVLSSAYALVDADDVMTKEEQIFLLHRAQAQCEKRLKEVLQRPASIMESDKGWTSASTSGKPRKDKASGKLYPESEEDKEAPTGSRYRGRPCLPEWDHILCWPLGAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVKFLTNETREREVFDRLGMIYTVGYSVSLASLTVAVLILAYFRRLHCTRNYIHMHLFLSFMLRAVSIFVKDAVLYSGATLDEAERLTEEELRAIAQAPPPPATAAAGYAGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTVFGWGLPAVFVAVWVSVRATLANTGCWDLSSGNKKWIIQVPILASIVLNFILFINIVRVLATKLRETNAGRCDTRQQYRKLLKSTLVLMPLFGVHYIVFMATPYTEVSGTLWQVQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIKKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRVGLGLPLSPRLLPTATTNGHPQLPGHAKPGTPALETLETTPPAMAAPKDDGFLNGSCSGLDEEASGPERPPALLQEEWETVM
UniProt	Q03431
Protein Data Bank	6fj3, 3h3g, 3c4m
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 6fj3.
BioLiP	BL0161387, BL0433539,BL0433540, BL0161388, BL0143680,BL0143682, BL0143681,BL0143683
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1793
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	GNF-Pf-3343
Molecular formula	C21H27ClN4OS
IUPAC name	3-(4-chlorophenyl)-N-[2-(dipropylamino)ethyl]-1-methylthieno[2,3-c]pyrazole-5-carboxamide
Molecular weight	418.984
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	5.3
Synonyms	3-(4-chlorophenyl)-N-[2-(dipropylamino)ethyl]-1-methylthieno[2,3-c]pyrazole-5-carboxamide HMS1826E01 C509-0116 MLS001199353 3-(4-chlorophenyl)-N-[2-(dipropylamino)ethyl]-1-methyl-5-thieno[2,3-c]pyrazolecarboxamide cid_16007420 SMR000560359 AKOS001819039 HMS2875J05 MolPort-007-635-639 3-(4-chlorophenyl)-N-[2-(dipropylamino)ethyl]-1-methyl-thieno[2,3-c]pyrazole-5-carboxamide ZINC5025926 BDBM51913 MCULE-8675634474 3-(4-chlorophenyl)-N-[2-(dipropylamino)ethyl]-1-methyl-1H-thieno[2,3-c]pyrazole-5-carboxamide CHEMBL599943 NCGC00108997-01 [ Show all ]
Inchi Key	HGWOFUAZIPRWPO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H27ClN4OS/c1-4-11-26(12-5-2)13-10-23-20(27)18-14-17-19(24-25(3)21(17)28-18)15-6-8-16(22)9-7-15/h6-9,14H,4-5,10-13H2,1-3H3,(H,23,27)
PubChem CID	16007420
ChEMBL	CHEMBL599943
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Potency	100000.0 nM	PubChem BioAssay data set	ChEMBL

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