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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Cannabinoid receptor 1
Species	Mus musculus (Mouse)
Gene	Cnr1
Synonym	SKR6R Neuronal cannabinoid receptor Central cannabinoid receptor CB1R CB1 receptor CB1 CB-R Cann7 Cann6 Brain-type cannabinoid receptor THC receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	473
Amino acid sequence	MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEDNIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNTASMHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
UniProt	P47746
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3037
IUPHAR	56
DrugBank	N/A

Ligand

Name	CHEMBL120935
Molecular formula	C24H41NO2
IUPAC name	(5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)docosa-5,8,11,14-tetraenamide
Molecular weight	375.597
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	6.4
Synonyms	(5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)docosa-5,8,11,14-tetraenamide N-(5Z,8Z,11Z,14Z-docosatetraenoyl)-ethanolamine AC1NR2CA (5Z,8Z,11Z,14Z)-Docosa-5,8,11,14-tetraenoic acid (2-hydroxy-ethyl)-amide 5,8,11,14-all-cis-docosatetraenoylethanolamine BDBM50060614 (5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)-5,8,11,14-docosatetraenamide LMFA08040021 [ Show all ]
Inchi Key	CPDDSZIDSJTTSS-GKFVBPDJSA-N
Inchi ID	InChI=1S/C24H41NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-24(27)25-22-23-26/h8-9,11-12,14-15,17-18,26H,2-7,10,13,16,19-23H2,1H3,(H,25,27)/b9-8-,12-11-,15-14-,18-17-
PubChem CID	5283460
ChEMBL	CHEMBL120935
IUPHAR	N/A
BindingDB	50060614
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	55.0 nM	PMID9357528	BindingDB,ChEMBL
Ki	1780.0 nM	PMID9357528	BindingDB,ChEMBL

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